Gallium nitrate in prostatic cancer: Evaluation of antitumor activity and effects on bone turnover Journal Article

  


Authors: Scher, H. I.; Curley, T.; Geller, N.; Dershaw, D.; Chan, E.; Nisselbaum, J.; Alcock, N.; Hollander, P.; Yagoda, A.
Article Title: Gallium nitrate in prostatic cancer: Evaluation of antitumor activity and effects on bone turnover
Abstract: Gallium nitrate, an agent known to inhibit bone resorption, was evaluated in patients with bidimensionally measurable hormone-refractory prostatic cancer. The starting dose was 200 mg/m2 iv by continuous infusion over 7 days. Two patients (10%; 95% confidence limits, 0%-22%) achieved short partial remissions of 1 and 6+ months, while seven of 23 (30%; 95% confidence limits, 14%-52%) showed a diminution of bone pain. Serial indices of bone turnover including serum calcium, phosphorus, and urinary hydroxyproline excretion showed a significant decrease at the completion of the infusion which returned to baseline prior to the next cycle. The data suggest the effect on bone was too short to produce consistent improvement. Reasons for the dissociation of pain relief and antitumor activity are discussed.
Keywords: clinical article; aged; bone neoplasms; bone metastasis; adenocarcinoma; pain; calcium; creatinine; calcium blood level; prostate cancer; prostatic neoplasms; bone; bone and bones; therapy; clinical trials; bone resorption; phosphorus; bone turnover; middle age; gallium; phosphate blood level; male genital system; gallium nitrate; human; male; hydroxyproline; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: Cancer Treatment Reports
Volume: 71
Issue: 10
ISSN: 0361-5960
Publisher: National Cancer Institute  
Date Published: 1987-10-01
Start Page: 887
End Page: 893
Language: English
PUBMED: 3308078
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023617323&partnerID=40&md5=582b2e6ce89dc18aa4d4be32e9003243
Notes: Article -- Export Date: 5 February 2021 -- Source: Scopus
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MSK Authors
  1. D David Dershaw
    223 Dershaw
  2. Tracy B Smart-Curley
    70 Smart-Curley
  3. Howard Scher
    1130 Scher
  4. Jerome S Nisselbaum
    20 Nisselbaum
  5. Nancy Alcock
    23 Alcock
  6. Nancy L. Geller
    65 Geller
  7. Alan Yagoda
    51 Yagoda
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