Phase II trial of carboplatin in patients with advanced germ cell tumors refractory to cisplatin Journal Article
| Authors: | Motzer, R. J.; Bosl, G. J.; Tauer, K.; Golbey, R. |
| Article Title: | Phase II trial of carboplatin in patients with advanced germ cell tumors refractory to cisplatin |
| Abstract: | A phase II trial of carboplatin was conducted in 22 patients with advanced germ cell tumors refractory to cisplatin-based chemotherapy. Twenty of 22 patients were evaluable for toxicity and response. Two partial responses and one minor response were seen. The major toxic effect was myelosuppression. Carboplatin has antitumor activity in patients with advanced germ cell tumors refractory to cisplatin, and phase II and III studies of combination chemotherapy are indicated. |
| Keywords: | adolescent; adult; cancer chemotherapy; clinical article; cisplatin; drug efficacy; comparative study; carboplatin; nephrotoxicity; phase 2 clinical trial; etoposide; nausea; vomiting; lung neoplasms; drug administration schedule; cyclophosphamide; dexamethasone; vinblastine; gastrointestinal toxicity; kidney; dactinomycin; bleomycin; drug toxicity; neoplasms, germ cell and embryonal; drug therapy; organoplatinum compounds; germ cell tumor; metoclopramide; adverse drug reaction; therapy; intravenous drug administration; diphenhydramine; female genital system; middle age; bone marrow depression; drug evaluation; intoxication; human; male; priority journal; support, u.s. gov't, p.h.s.; blood and hemopoietic system |
| Journal Title: | Cancer Treatment Reports |
| Volume: | 71 |
| Issue: | 2 |
| ISSN: | 0361-5960 |
| Publisher: | National Cancer Institute |
| Date Published: | 1987-02-01 |
| Start Page: | 197 |
| End Page: | 198 |
| Language: | English |
| PUBMED: | 3026627 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
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