Systemic absorption of a leucovorin mouth wash: A pharmacologic study Journal Article
| Authors: | Fiore, J. J.; Kemeny, N. E.; Mehta, B. M.; Geller, N.; Grossano, D.; Murphy, D. |
| Article Title: | Systemic absorption of a leucovorin mouth wash: A pharmacologic study |
| Abstract: | Mucositis is one of the major problems encountered after the administration of systemic chemotherapy. Leucovorin, routinely used as a rescue agent for methotrexate may reduce toxicity, but may also reduce the effectiveness of the chemotherapeutic agent. If leucovorin is administered as a mouth wash, local toxicity may be reduced without loss of methotrexate efficacy. In order to study this, 15 normal human volunteers were given leucovorin mouth wash and then had plasma determinations of 5-methyl-tetrahydrofolate and citrovorum factor. Small but statistically significant increases in plasma levels of 5-methyl-tetrahydrofolate were observed with no increase in levels of plasma citrovorum factor. It is concluded therefore that a small amount of leucovorin is absorbed systemically when administered as a mouth wash, but such an amount would most likely not be significant enough to reduce the effect of methotrexate therapy, but may reduce mucositis. © 1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| Keywords: | adult; cancer chemotherapy; clinical article; middle aged; drug efficacy; methotrexate; mucosa inflammation; folinic acid; drug blood level; administration, oral; folinate calcium; leucovorin; adverse drug reaction; mouth; therapy; pharmacology; blood level; mouth hygiene; mouthwashes; absorption; intoxication; humans; human; male; female; blood and hemopoietic system; mouth diseases |
| Journal Title: | Cancer Investigation |
| Volume: | 5 |
| Issue: | 2 |
| ISSN: | 0735-7907 |
| Publisher: | Informa Healthcare |
| Date Published: | 1987-01-01 |
| Start Page: | 109 |
| End Page: | 111 |
| Language: | English |
| DOI: | 10.3109/07357908709018464 |
| PUBMED: | 3496943 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
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