The use of indomethacin, sulindac, and tamoxifen for the treatment of desmoid tumors associated with familial polyposis Journal Article


Authors: Klein, W. A.; Miller, H. H.; Anderson, M.; DeCosse, J. J.
Article Title: The use of indomethacin, sulindac, and tamoxifen for the treatment of desmoid tumors associated with familial polyposis
Abstract: Seven familial polyposis patients with desmoid tumors were treated with indomethacin, sulindac, or tamoxifen either as single agents or in combination. Serial computed tomographic (CT) scan examination was employed for objective measurement of tumor size since physical examination alone was an inaccurate means to evaluate intraabdominal and retroperitoneal desmoids. Only one patient with minimal tumor burden demonstrated a favorable response with complete resolution of an abdominal wall desmoid. Copyright © 1987 American Cancer Society
Keywords: adult; clinical article; computer assisted tomography; antineoplastic combined chemotherapy protocols; indometacin; sulindac; tamoxifen; fibroma; indenes; desmoid tumor; computer analysis; polyposis; adenomatous polyposis coli; indomethacin; human; male; female; support, u.s. gov't, p.h.s.
Journal Title: Cancer
Volume: 60
Issue: 12
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 1987-12-15
Start Page: 2863
End Page: 2868
Language: English
DOI: 10.1002/1097-0142(19871215)60:12<2863::Aid-cncr2820601202>3.0.Co;2-i
PUBMED: 2824015
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 5 February 2021 -- Source: Scopus
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  1. Helen H Miller
    6 Miller
  2. Jerome J. DeCosse
    25 DeCosse