Testicular failure in patients with extragonadal germ cell tumors Journal Article
| Authors: | Carroll, P. R.; Whitmore, W. F. Jr; Richardson, M.; Bajorunas, D.; Herr, H. W.; Williams, R. D.; Fair, W. R.; Chaganti, R. S. K. |
| Article Title: | Testicular failure in patients with extragonadal germ cell tumors |
| Abstract: | Eight patients with mediastinal or retroperitoneal germ cell tumors who had undergone testicular biopsy or orchiectomy were retrospectively analyzed for primary testicular abnormalities, subfertility, and abnormal sex hormone levels. Testicular tissue was abnormal in all patients, revealing peritubular fibrosis (six), decreased spermatogenesis (eight), interstitial edema (five), Sertoli cells only (one), and Leydig cell hyperplasia (two). Detailed hormone analysis in five patients revealed elevations of luteinizing hormone in four, decreased serum testosterone in two, elevations of estradiol in two, and elevation of human chorionic gonadotropin in one patient. A history of infertility was documented 2 months to 13 years before presentation in four patients and suspected in another. Extragonadal germ cell tumors, like their testicular counterparts are associated with primary germ cell defects, some of which seem to be independent of gonadotropin production by the tumor. In addition, the rather high incidence of antecedent infertility suggests that either a congenital or acquired primary germ cell defect contributes to defective spermatogenesis and the development of cancer in incompletely migrated germ cells. Copyright © 1987 American Cancer Society |
| Keywords: | adolescent; adult; clinical article; middle aged; retrospective studies; combined modality therapy; follow-up studies; peritoneal neoplasms; infertility; diagnosis; retroperitoneal tumor; neoplasms, germ cell and embryonal; retroperitoneal neoplasms; orchiectomy; mediastinum; germ cell tumor; mediastinum tumor; testis; retroperitoneum; hormones; etiology; infertility, male; male genital system; testis biopsy; humans; human; male; priority journal; paraneoplastic endocrine syndromes |
| Journal Title: | Cancer |
| Volume: | 60 |
| Issue: | 1 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1987-07-01 |
| Start Page: | 108 |
| End Page: | 113 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19870701)60:1<108::Aid-cncr2820600120>3.0.Co;2-8 |
| PUBMED: | 3034394 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus -- Acknowledgements: The authors thank Philip Lieberman, MD, for his careful review of the manuscript and histologic material |
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