Combined modality treatment of locally advanced breast cancer: Adjuvant combination chemotherapy with and without doxorubicin Journal Article
| Authors: | Casper, E. S.; Guidera, C. A.; Bosl, G. J.; Hakes, T. B.; Kaufman, R. J.; Shurgot, B.; Kinne, D. W. |
| Article Title: | Combined modality treatment of locally advanced breast cancer: Adjuvant combination chemotherapy with and without doxorubicin |
| Abstract: | Forty-one women with non-metastatic but locally advanced breast cancer were treated by modified radical or radical mastectomy, and were then randomized to receive one of two adjuvant chemotherapy regimens. Regimen A consisted of 6 months of cyclophosphamide, adriamycin, and fluorouracil (CAF) followed by 6 months of cyclophosphamide, methotrexate, fluorouracil, vincristine, and prednisone (CMFVP). Regimen B was 12 months of CMFVP. Patients were stratified for estrogen-receptor status, and all patients with a positive estrogen receptor value received tamoxifen 20 mg bid in addition to the chemotherapy. Eight of 21 patients radomized to Regimen A are alive and free of disease, whereas only 1 of 20 patients on Regimen B is well. A trend toward improved disease-free survival favoring Regimen A was observed (P = .05), although a significant difference in overall survival has not been demonstrated. Our findings support the continued study of adriamycin-containing regimens in the adjuvant setting and in combined modality therapy of locally advanced breast cancer. © 1987 Martinus Nijhoff Publishers. |
| Keywords: | adult; cancer chemotherapy; clinical article; aged; middle aged; prednisone; doxorubicin; fluorouracil; cancer combination chemotherapy; combined modality therapy; methotrexate; metastasis; breast; antineoplastic combined chemotherapy protocols; cyclophosphamide; vincristine; breast neoplasms; adjuvant chemotherapy; tamoxifen; therapy; intravenous drug administration; humans; human; female; locally advanced breast cancer; caf; cmfvp |
| Journal Title: | Breast Cancer Research and Treatment |
| Volume: | 9 |
| Issue: | 1 |
| ISSN: | 0167-6806 |
| Publisher: | Springer |
| Date Published: | 1987-02-01 |
| Start Page: | 39 |
| End Page: | 44 |
| Language: | English |
| DOI: | 10.1007/bf01806692 |
| PUBMED: | 3593990 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
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