Interferone, interleukin-2 und tumor nekrose faktor: Neue ansätze krebsbehandlung Journal Article
| Author: | Oettgen, H. F. |
| Article Title: | Interferone, interleukin-2 und tumor nekrose faktor: Neue ansätze krebsbehandlung |
| Abstract: | Lymphokines represent a new group of substances that have engendered increasing interest in the context of cancer therapy. They are products of the lymphoid system that can now be produced in pure form as a consequence of advances in gene cloning technology. α-Interferon has been tested in clinical trials for several years, and has been found effective in the treatment of patients with hairy cell leukaemia, chronic myelogenous leukemia, Kaposi's sarcoma (AIDS) and renal cell cancer. Interleukin-2 has shown impressive antitumor activity in patients with melanoma or renal cell cancer, particularly in combination with lymphokine-activated killer cells, although at very high doses with correspondingly severe toxicity. The clinical testing of tumor necrosis factor is in an early stage. The introduction of this class of agents has opened new perspectives for cancer therapy. |
| Keywords: | cancer chemotherapy; clinical article; review; drug efficacy; alpha interferon; neoplasms; interleukin 2; cancer immunotherapy; cancer therapy; drug dose; kaposi sarcoma; glycoproteins; therapy; intravenous drug administration; interleukin-2; pharmacology; tumor necrosis factor; hairy cell leukemia; myeloid leukemia; growth inhibitors; interferons; human; priority journal; lymphokine; english abstract; blood and hemopoietic system |
| Journal Title: | Arzneimittel-Forschung |
| Volume: | 37 |
| Issue: | 2 A |
| ISSN: | 0004-4172 |
| Publisher: | Georg Thieme Verlag |
| Date Published: | 1987-02-01 |
| Start Page: | 251 |
| End Page: | 255 |
| Language: | German |
| PUBMED: | 2436634 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | "Interferons, interleukin-2 and tumor necrosis factor: New approaches to cancer therapy" -- Review -- Export Date: 5 February 2021 -- Source: Scopus |
