The acute metabolic effects of tumor necrosis factor administration in humans Journal Article
| Authors: | Warren, R. S.; Starnes, H. F. Jr; Gabrilove, J. L.; Oettgen, H. F.; Brennan, M. F. |
| Article Title: | The acute metabolic effects of tumor necrosis factor administration in humans |
| Abstract: | It has been suggested that the monokine tumor necrosis factor (TNF) (cachectin) is responsible for metabolic abnormalities frequently accompanying malignant neoplasms. The acute metabolic effects of TNF in patients with cancer were studied. Subcutaneous administration of recombinant human TNF led to a rise in the C-reactive protein level (4.4±1.2 mg/dL vs 11.6±1.8 mg/dL) and a reduction in the serum zinc level (12.9±0.8 μmol/L vs 7.3±0.8 μmol/L [79± 5 mg/dL vs 48±5 mg/dL]) (values are the mean±SEM). Forearm efflux of total amino acids more than doubled after intravenous TNF injection, principally because of increases in release of the gluconeogenic amino acids alanine and glutamine. Concomitantly, the arterial levels of alanine, glutamine, and total amino acids fell, indicating that TNF also stimulated the uptake of amino acids by other tissues. The observed amino acid pattern cannot be explained solely on the basis of measured changes in cortisol, glucagon, or insulin levels. These findings are discussed in relation to known alterations of amino acid metabolism in cancer-associated cachexia. © 1987, American Medical Association. All rights reserved. |
| Keywords: | adult; comparative study; research design; neoplasms; c reactive protein; c-reactive protein; time factors; recombinant proteins; cachexia; amino acids; zinc; injections, subcutaneous; infusions, intravenous; tumor necrosis factor; human experiment; glucocorticoids; serum albumin; drug evaluation; human; male; female; support, u.s. gov't, p.h.s. |
| Journal Title: | Archives of Surgery |
| Volume: | 122 |
| Issue: | 12 |
| ISSN: | 0004-0010 |
| Publisher: | American Medical Association |
| Date Published: | 1987-12-01 |
| Start Page: | 1396 |
| End Page: | 1400 |
| Language: | English |
| DOI: | 10.1001/archsurg.1987.01400240042007 |
| PUBMED: | 3689116 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus; Acknowledgements: Mark Slattery, Paul Leo, Martha Uhl, and Anthony Tolvo provided technical assistance; Nancy Alcock, PhD, determined serum zinc levels; and Paul B. Chapman, MD, Thomas J. Lester, MD, Ephraim Casper, MD, Lucy A. Dantis, RN, Linda M. Potanovich, RN, and Theresa N. Oleske, RN, provided clinical support |
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