Chromosome anomalies as predictors of recurrence risk for spontaneous abortion Journal Article
| Authors: | Morton, N. E.; Chiu, D.; Holland, C.; Jacobs, P. A.; Pettay, D. |
| Article Title: | Chromosome anomalies as predictors of recurrence risk for spontaneous abortion |
| Abstract: | Reproductive histories and chromosomes of spontaneous abortions were studied by segregation analysis in 1890 sibships ascertained through a cytogenetically studied abortion. Normal karyotypes are associated with recurrent abortion. Among abnormal karyotypes, trisomy has an elevated recurrence risk even after adjustment through a liability indicator for maternal age. Possible mechanisms and conflicting evidence in the literature on trisomy are discussed. None of these differences in recurrence risk is large enough to play a significant numerical role in genetic counseling. |
| Keywords: | recurrence risk; chromosome aberration; genetic risk; karyotype; genetic counseling; trisomy; spontaneous abortion; human |
| Journal Title: | American Journal of Medical Genetics |
| Volume: | 28 |
| Issue: | 2 |
| ISSN: | 0148-7299 |
| Publisher: | Wiley Liss |
| Date Published: | 1987-10-01 |
| Start Page: | 353 |
| End Page: | 360 |
| Language: | English |
| DOI: | 10.1002/ajmg.1320280213 |
| PUBMED: | 3322004 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 5 February 2021 -- Source: Scopus |
