Total synthesis of (+)-isomigrastatin Journal Article

  


Authors: Krauss, I. J.; Mandal, M.; Danishefsky, S. J.
Article Title: Total synthesis of (+)-isomigrastatin
Abstract: (Chemical Equation Presented) Marginally stable natural products: The asymmetric total synthesis of the hydrolytically and thermally labile natural product (+)-isomigrastatin was demonstrated. The thermodynamic instability of a 2E-configured double bond in the context of this 12-membered macrolide was further demonstrated by phosphine-catalyzed isomerization to the 2Z configuration. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
Keywords: unclassified drug; proteins; chemistry; chemical structure; molecular structure; macrolide; hydrolysis; synthesis; total synthesis; catalyst activity; lactones; isomerization; inhibitors; metathesis; natural products; piperidone derivative; macrolides; piperidones; chemical bonds; lactone; isomerism; isomigrastatin
Journal Title: Angewandte Chemie - International Edition
Volume: 46
Issue: 29
ISSN: 1433-7851
Publisher: Wiley Blackwell  
Date Published: 2007-01-01
Start Page: 5576
End Page: 5579
Language: English
DOI: 10.1002/anie.200701837
PUBMED: 17583888
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-34547183333&partnerID=40&md5=6735b94c92c23dc04f4507469733a8d9
Notes: --- - "Cited By (since 1996): 12" - "Export Date: 17 November 2011" - "CODEN: ACIEA" - "Source: Scopus"
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MSK Authors
  1. Isaac Krauss
    6 Krauss
  2. Samuel J Danishefsky
    539 Danishefsky
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