Partial penectomy for patients with squamous cell carcinoma of the penis: The Memorial Sloan-Kettering experience Journal Article

  

Authors:	Korets, R.; Koppie, T. M.; Snyder, M. E.; Russo, P.
Article Title:	Partial penectomy for patients with squamous cell carcinoma of the penis: The Memorial Sloan-Kettering experience
Abstract:	Background: To present our institution's experience with squamous cell carcinoma (SCC) of the penis, with analysis of oncologic efficacy and survival. Methods: Between 1989 and 2005, we identified 32 consecutive patients (median age, 61 years) with SCC of the penis managed with partial penectomy. Clinicopathologic variables were examined, and overall and disease-specific survival were determined. Results: Pathologic stage of the primary tumor was pTis in 1 patient (3%), pT1 in 11 (34%), pT2 in 16 (50%), and pT3 in 4 (13%). Pathologic grade was well differentiated in 9 patients (28%), moderately differentiated in 20 (63%), and poorly differentiated in 2 (6%). Twenty-five patients (78%) underwent inguinal lymph node dissection, with 15 (60%) demonstrating nodal metastases. Twenty-two patients (69%) underwent pelvic lymph node dissection; 21 were negative for pelvic nodal metastases, and 1 had grossly positive nodes. One patient developed local recurrence. After a mean follow-up of 34 months, overall survival was 56%. Numbers of patients alive and disease-free were 9 and 11 in the low-stage and advanced-stage groups, and 8 and 12 in the well and moderately differentiated groups, respectively. Both patients with poorly differentiated disease died of disease within 12 months from presentation. Conclusions: Partial penectomy for SCC of the penis provides excellent local control, with low recurrence rate, and acceptable maintenance of urinary and sexual function. Outcomes are generally poor, however, for patients with regional metastases, even in moderately differentiated disease. Future studies are needed to identify a reliable method of predicting regional metastases. © 2007 Society of Surgical Oncology.
Keywords:	adult; clinical article; human tissue; aged; aged, 80 and over; middle aged; survival rate; overall survival; cancer recurrence; squamous cell carcinoma; carcinoma, squamous cell; cancer patient; disease free survival; cancer staging; outcome assessment; follow up; follow-up studies; lymph node metastasis; antineoplastic agent; lymph node dissection; pelvis lymph node; lymph node excision; prospective studies; neoplasm recurrence, local; pathology; prediction; time factors; cancer center; experience; inguinal lymph node; penis amputation; penis carcinoma; penile neoplasms; cancer control; urologic surgical procedures, male; sexual function; urinary tract function
Journal Title:	Annals of Surgical Oncology
Volume:	14
Issue:	12
ISSN:	1068-9265
Publisher:	Springer
Date Published:	2007-12-01
Start Page:	3614
End Page:	3619
Language:	English
DOI:	10.1245/s10434-007-9563-9
PUBMED:	17896151
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-36349017136&partnerID=40&md5=083b2bc9473cc77926268725e82ab031
Notes:	--- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "CODEN: ASONF" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/17650