Association of interleukin-6 and tumor necrosis factor-α with mortality in hospitalized patients with cancer Journal Article
| Authors: | Stoll, J. R.; Vaidya, T. S.; Mori, S.; Dusza, S. W.; Lacouture, M. E.; Markova, A. |
| Article Title: | Association of interleukin-6 and tumor necrosis factor-α with mortality in hospitalized patients with cancer |
| Abstract: | Background: Severe cutaneous adverse reactions (SCARs) are associated with high morbidity and mortality in patients with cancer. Early identification and treatment of SCARs may improve outcomes. Objective: To identify biomarkers to predict outcomes in hospitalized patients with cancer who developed SCARs. Methods: Retrospective review of 144 hospitalized patients with cancer with a morbilliform rash, recorded testing for serum cytokines (interleukin [IL]-6, IL-10, and tumor necrosis factor [TNF]-α) or elafin, and a dermatology consultation. Rashes were categorized as simple morbilliform rash without systemic involvement or complex morbilliform rash with systemic involvement. Results: Fifty-four of 144 (37.5%) patients died during follow-up. Elevated levels of IL-6, IL-10, and TNF-α were associated with decreased survival. Overall survivals in patients with elevated levels of IL-6, IL-10, and TNF-α were 53.7%, 56.6%, 53.6%, respectively, compared with 85.7%, 82.5% and 83.6%, respectively, in those with lower levels. Patients with increased levels of both IL-6 and TNF-α had a nearly 6-fold increase in mortality (hazard ratio, 5.82) compared with patients with lower levels. Limitations: Retrospective design, limited sample size, and high-risk population. Conclusions: Hospitalized patients with cancer with rash and elevated IL-6 and TNF-α were nearly 6 times more likely to die over the course of follow-up. These biomarkers may serve as prognostic biomarkers and therapeutic targets for this high-risk population. © 2020 American Academy of Dermatology, Inc. |
| Keywords: | survival; mortality; cytokine; biomarker; graft-versus-host disease; drug reaction; drug rash; drug reaction with eosinophilia and systemic symptoms; drug-induced hypersensitivity syndrome; severe cutaneous adverse reaction; interleukin-6 (il-6); tumor necrosis factor alpha (tnf-α) |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 84 |
| Issue: | 2 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2021-02-01 |
| Start Page: | 273 |
| End Page: | 282 |
| Language: | English |
| DOI: | 10.1016/j.jaad.2020.03.010 |
| PUBMED: | 32171811 |
| PROVIDER: | scopus |
| PMCID: | PMC7486231 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2021 -- Source: Scopus |
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