Nodal disease burden and outcome of medullary thyroid carcinoma Journal Article
| Authors: | Moses, L. E.; Oliver, J. R.; Rotsides, J. M.; Shao, Q.; Patel, K. N.; Morris, L. G. T.; Givi, B. |
| Article Title: | Nodal disease burden and outcome of medullary thyroid carcinoma |
| Abstract: | Background: Medullary thyroid carcinoma (MTC) is a rare malignancy with high incidence of cervical lymph node (CLN) metastasis. We investigated the impact of nodal disease burden on survival. Methods: We searched the National Cancer Database for MTC patients treated surgically. Impact of nodal metastasis on survival was analyzed using Cox univariable and multivariable regression. Results: We identified 2627 patients from 2004 to 2015. Positive CLNs were identified in 1433 (54.5%), and 542 (20.6%) had >10 CLN+. Overall survival was 94.5% and 89.6% at 3 and 5 years. Patients with 11 to 20 CLN+ had significantly worse survival than patients with 1 to 10 CLN+ in univariable and multivariable analyses (HR = 3.56 (2.31-5.50) vs 2.26 (1.60-3.20); P <.0001). The ratio of positive to dissected CLN was associated with overall survival. Conclusions: Higher burden of nodal disease is associated with worse survival in MTC. The number of positive nodes could be a valuable prognosticator in addition to the current staging system. © 2020 Wiley Periodicals LLC |
| Keywords: | adult; cancer chemotherapy; cancer survival; controlled study; cancer surgery; major clinical study; overall survival; multimodality cancer therapy; cancer radiotherapy; cancer staging; antineoplastic agent; lymph node dissection; data base; information retrieval; cancer registry; tumor classification; thyroid medullary carcinoma; lymph vessel metastasis; disease burden; human; male; female; priority journal; article; cervical lymph node metastasis |
| Journal Title: | Head & Neck |
| Volume: | 43 |
| Issue: | 2 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2021-02-01 |
| Start Page: | 577 |
| End Page: | 584 |
| Language: | English |
| DOI: | 10.1002/hed.26511 |
| PUBMED: | 33107153 |
| PROVIDER: | scopus |
| PMCID: | PMC8414417 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2021 -- Source: Scopus |
