Toxicity and efficacy of intravitreal melphalan for retinoblastoma: 25 μg versus 30 μg Journal Article
| Authors: | Liao, A.; Hsieh, T.; Francis, J. H.; Lavery, J. A.; Mauguen, A.; Brodie, S. E.; Abramson, D. H. |
| Article Title: | Toxicity and efficacy of intravitreal melphalan for retinoblastoma: 25 μg versus 30 μg |
| Abstract: | PURPOSE: To compare retinal toxicity as measured by electroretinogram, ocular, and patient survival in retinoblastoma treated with intravitreal melphalan at two concentrations (25 vs. 30 μg). METHODS: Single-center, retrospective analysis of retinoblastoma eyes receiving 25-μg or 30-μg intravitreal melphalan from September 2012 to January 2019. Ocular toxicity was measured by electroretinogram of evaluable injections in 449 injections in 136 eyes. A repeated-measures linear mixed model with a random intercept and slope was applied to account for repeated measures for each eye. RESULTS: Average decline in electroretinogram after each additional injection was -4.9 μV (95% confidence interval -6.3 to -3.4); electroretinogram declined by -4.6 μV (95% confidence interval -7.0 to -2.2) after 25-μg injections and -5.2 μV (95% confidence interval -6.6 to -3.8) after 30-μg injections (P = 0.66). Injection at a new clock site hour was associated with a -3.91-μV lower average (95% confidence interval -7.8 to -0.04). CONCLUSION: Electroretinogram-measured toxicity in retinoblastoma eyes treated with intravitreal injections was not found to be different across 25-μg and 30-μg injections. There were no cases of extraocular extension or metastatic deaths in our patient population. |
| Journal Title: | Retina |
| Volume: | 41 |
| Issue: | 1 |
| ISSN: | 0275-004X |
| Publisher: | Wolters Kluwer |
| Date Published: | 2021-01-01 |
| Start Page: | 208 |
| End Page: | 212 |
| Language: | English |
| DOI: | 10.1097/iae.0000000000002782 |
| PUBMED: | 32106160 |
| PROVIDER: | scopus |
| PMCID: | PMC7483207 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2021 -- Source: Scopus |
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