A dual-modal PET/near infrared fluorescent nanotag for long-term immune cell tracking Journal Article
| Authors: | Harmsen, S.; Medine, E. I.; Moroz, M.; Nurili, F.; Lobo, J.; Dong, Y.; Turkekul, M.; Pillarsetty, N. V. K.; Ting, R.; Ponomarev, V.; Akin, O.; Aras, O. |
| Article Title: | A dual-modal PET/near infrared fluorescent nanotag for long-term immune cell tracking |
| Abstract: | Adoptive cell transfer of targeted chimeric antigen receptor (CAR) T cells has emerged as a highly promising cancer therapy. The pharmacodynamic action or CAR T cells is closely related to their pharmacokinetic profile; because of this as well as the risk of non-specific action, it is important to monitor their biodistribution and fate following infusion. To this end, we developed a dual-modal PET/near infrared fluorescent (NIRF) nanoparticle-based imaging agent for non-genomic labeling of human CAR T cells. Since the PET/NIRF nanoparticles did not affect cell viability or cytotoxic functionality and enabled long-term whole-body CAR T cell tracking using PET and NIRF in an ovarian peritoneal carcinomatosis model, this platform is a viable imaging technology to be applied in other cancer models. © 2020 Elsevier Ltd |
| Keywords: | cytology; cell viability; fluorescence; cancer therapy; nanoparticles; nanomedicine; pet; diseases; t-cells; tracking; imaging techniques; imaging technology; peritoneal carcinomatosis; biodistributions; antigen receptors; near-infrared fluorescence; cancer models; pharmacokinetic profiles; dual-modal; immune cell labeling |
| Journal Title: | Biomaterials |
| Volume: | 269 |
| ISSN: | 0142-9612 |
| Publisher: | Elsevier |
| Date Published: | 2021-02-01 |
| Start Page: | 120630 |
| Language: | English |
| DOI: | 10.1016/j.biomaterials.2020.120630 |
| PROVIDER: | scopus |
| PUBMED: | 33395580 |
| PMCID: | PMC7870530 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2021 -- Source: Scopus |
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