Intestinal microbes in autoimmune and inflammatory disease Review
| Authors: | Wu, W. J. H.; Zegarra-Ruiz, D. F.; Diehl, G. E. |
| Review Title: | Intestinal microbes in autoimmune and inflammatory disease |
| Abstract: | Autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation. Multiple factors including genetic variation, environmental stimuli, and infection are all thought to contribute to continued inflammation and pathology. Current evidence supports the microbiota as one such factor with emerging data linking commensal organisms to the onset and progression of disease. In this review, we will discuss links between the microbiota and specific diseases as well as highlight common pathways that link intestinal microbes with multiple autoimmune and inflammatory diseases. © Copyright © 2020 Wu, Zegarra-Ruiz and Diehl. |
| Keywords: | gene mutation; review; nonhuman; interleukin 10; inflammation; cell differentiation; immune response; autoimmunity; systemic lupus erythematosus; intestine flora; autoimmune disease; insulin dependent diabetes mellitus; multiple sclerosis; toll like receptor; interleukin 22; crohn disease; aromatic hydrocarbon receptor; caspase recruitment domain protein 15; inflammatory disease; type 1 diabetes; microbial community; intestinal microbiota; bifidobacterium; interleukin 10 receptor; inflammatory bowel disease; inflammasome; bacterial translocation; human; lachnospiraceae; rheumathoid arthritis; nucleotide binding oligomerization domain protein; lactobacillus delbrueckii subsp. bulgaricus; propionibacterium; propionibacterium propionicum |
| Journal Title: | Frontiers in Immunology |
| Volume: | 11 |
| ISSN: | 1664-3224 |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2020-12-23 |
| Start Page: | 597966 |
| Language: | English |
| DOI: | 10.3389/fimmu.2020.597966 |
| PUBMED: | 33424846 |
| PROVIDER: | scopus |
| PMCID: | PMC7786055 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 February 2021 -- Source: Scopus |
