ITGCN of the testis, contralateral testicular biopsy and bilateral testicular cancer Journal Article
| Authors: | Karellas, M. E.; Damjanov, I.; Holzbeierlein, J. M. |
| Article Title: | ITGCN of the testis, contralateral testicular biopsy and bilateral testicular cancer |
| Abstract: | Over 30 years ago Skakkebæk was the first to characterize a noninvasive precursor lesion (intratubular germ cell neoplasia or carcinoma in situ) that would progress to invasive testicular tumors. In this article we discuss the molecular changes thought to cause this malignant transformation, various conditions that predispose to the development of testicular germ cell tumors, diagnostic strategies, and treatment options. Additionally we discuss the current patterns of contralateral testicular biopsy to identify intratubular germ cell neoplasia, as well as the incidence and management of bilateral testicular tumors. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | immunohistochemistry; adult; cancer chemotherapy; treatment response; cancer surgery; surgical technique; disease course; review; microscopy; cisplatin; cancer risk; cancer radiotherapy; cancer diagnosis; incidence; risk factor; high risk patient; time factors; risk assessment; gene expression regulation, neoplastic; biopsy, needle; carcinoma in situ; testicular neoplasms; neoplasms, germ cell and embryonal; biopsy technique; orchiectomy; cancer control; testis cancer; malignant transformation; germ cell tumor; octamer transcription factor-3; clinical trials; seminiferous tubules; testis biopsy |
| Journal Title: | Urologic Clinics of North America |
| Volume: | 34 |
| Issue: | 2 |
| ISSN: | 0094-0143 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2007-05-01 |
| Start Page: | 119 |
| End Page: | 125 |
| Language: | English |
| DOI: | 10.1016/j.ucl.2007.02.015 |
| PUBMED: | 17484917 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 17 November 2011" - "CODEN: UCNAD" - "Source: Scopus" |
