Niche-to-niche migration of bone-marrow-derived cells Journal Article
| Authors: | Kaplan, R. N.; Psaila, B.; Lyden, D. |
| Article Title: | Niche-to-niche migration of bone-marrow-derived cells |
| Abstract: | During ontogenesis, haematopoietic stem cells (HSCs) relocate between extra-embryonic and embryonic compartments. Similarly, site-specific homing of HSCs is ongoing during adulthood. With the expanding knowledge of HSC physiology, a new paradigm emerges in which HSCs and haematopoietic progenitor cells (HPCs) migrate to defined microenvironments within the bone marrow (BM) and to 'activated' or 'inducible' niches elsewhere. Here, we summarize current understanding of HSC niche characteristics, and the physiological and pathological mechanisms that guide HSC homing both within the BM and to distant niches in the periphery, promoting new vessel growth in tumours and ischaemia. Recent observations suggest that features of the HSC niche might also be recapitulated in pre-metastatic sites. Clusters of BM-derived HPCs promote invasion of disseminating cancer cells. Clear clinical benefits can be foreseen by modulating HSCs and their microenvironments, in promoting tissue regeneration, and inhibiting tumourigenesis and cancer metastasis. © 2006 Elsevier Ltd. All rights reserved. |
| Keywords: | signal transduction; controlled study; review; nonhuman; neoplasms; animals; bone marrow cells; cell function; metastasis; cluster analysis; models, biological; gelatinase b; stem cell transplantation; ischemia; stem cell mobilization; hematopoietic stem cells; cell migration; cell movement; cellular distribution; hematopoiesis; cathepsin k; bone marrow cell; microenvironment; hematopoietic stem cell; tumor growth; cell adhesion; neovascularization (pathology); cell invasion; vasculotropin receptor 1; blood vessels; osteoblast; osteoblasts; fetus development; fetal development; tissue specificity; stromal cell derived factor 1; osteopontin; very late activation antigen 4; calcium sensing receptor; chemokines, cxc; receptors, calcium-sensing; tumor stem cells |
| Journal Title: | Trends in Molecular Medicine |
| Volume: | 13 |
| Issue: | 2 |
| ISSN: | 1471-4914 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-02-01 |
| Start Page: | 72 |
| End Page: | 81 |
| Language: | English |
| DOI: | 10.1016/j.molmed.2006.12.003 |
| PUBMED: | 17197241 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 76" - "Export Date: 17 November 2011" - "CODEN: TMMRC" - "Source: Scopus" |
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