Reflectance confocal microscopy terminology glossary for melanocytic skin lesions: A systematic review Review


Authors: Navarrete-Dechent, C.; Liopyris, K.; Monnier, J.; Aleissa, S.; Boyce, L. M.; Longo, C.; Oliviero, M.; Rabinovitz, H.; Marghoob, A. A.; Halpern, A. C.; Pellacani, G.; Scope, A.; Jain, M.
Review Title: Reflectance confocal microscopy terminology glossary for melanocytic skin lesions: A systematic review
Abstract: Background: There is lack of uniformity in the reflectance confocal microscopy (RCM) terminology for melanocytic lesions. Objective: To review published RCM terms for melanocytic lesions and identify redundant, synonymous terms. Methods: A systematic review of original research articles adhering to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines was conducted until August 15, 2018. Two investigators gathered all published RCM terms used to describe melanoma and melanocytic nevi. Synonymous terms were grouped based on similarity in definition and in histopathologic correlation. Results: Out of 156 full-text screened articles, 59 studies met the inclusion criteria. We identified 209 terms; 191 (91.4%) corresponding to high-magnification/cellular-level terms and 18 (8.6%) corresponding to low-magnification/architectural patterns terms. The overall average use frequency of RCM terms was 3.1 times (range, 1-31). By grouping of individual RCM terms based on likely synonymous definitions and by eliminating terms lacking clear definition, the total number of RCM terms could be potentially reduced from 209 to 40 terms (80.8% reduction). Limitations: Non-English and non–peer-reviewed articles were excluded. Conclusions: This systematic review of published RCM terms identified significant terminology redundancy. It provides the basis for subsequent terminology consensus on melanocytic neoplasms. © 2020 American Academy of Dermatology, Inc.
Keywords: melanoma; reflectance confocal microscopy; nevus; systematic review; diagnosis; melanocytic; noninvasive
Journal Title: Journal of the American Academy of Dermatology
Volume: 84
Issue: 1
ISSN: 0190-9622
Publisher: Mosby Elsevier  
Date Published: 2021-01-01
Start Page: 102
End Page: 119
Language: English
DOI: 10.1016/j.jaad.2020.05.097
PUBMED: 32454102
PROVIDER: scopus
PMCID: PMC8387955
DOI/URL:
Notes: Review -- Export Date: 4 January 2021 -- Source: Scopus
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  1. Allan C Halpern
    396 Halpern
  2. Alon Scope
    125 Scope
  3. Ashfaq A Marghoob
    534 Marghoob
  4. Manu   Jain
    76 Jain
  5. Lindsay Marie Boyce
    18 Boyce
  6. Saud Aleissa
    24 Aleissa