Dermatoscopic features of thin (≤2 mm Breslow thickness) vs. thick (>2 mm Breslow thickness) nodular melanoma and predictors of nodular melanoma versus nodular non-melanoma tumours: A multicentric collaborative study by the International Dermoscopy Society Journal Article
| Authors: | Sgouros, D.; Lallas, A.; Kittler, H.; Zarras, A.; Kyrgidis, A.; Papageorgiou, C.; Puig, S.; Scope, A.; Argenziano, G.; Zalaudek, I.; Pizzichetta, M. A.; Marghoob, A.; Liopyris, K.; Malvehy, J.; Oikonomou, C.; Flórez, A.; Braun, R.; Cabo, H.; Nazzaro, G.; Lanssens, S.; Menzies, S.; Paoli, J.; Kaminska – Winciorek, G.; Longo, C.; Katoulis, A.; Apalla, Z.; Ioannides, D.; Thomas, L.; Tromme, I.; Ogata, D.; Desinioti, C.; Geller, A.; Stratigos, A. |
| Article Title: | Dermatoscopic features of thin (≤2 mm Breslow thickness) vs. thick (>2 mm Breslow thickness) nodular melanoma and predictors of nodular melanoma versus nodular non-melanoma tumours: A multicentric collaborative study by the International Dermoscopy Society |
| Abstract: | Background: Thin nodular melanoma (NM) often lacks conspicuous melanoma-specific dermatoscopic criteria and escapes clinical detection until it progresses to a thicker and more advanced tumour. Objective: To investigate the dermatoscopic morphology of thin (≤2 mm Breslow thickness) vs. thick (>2 mm) NM and to identify dermatoscopic predictors of its differential diagnosis from other nodular tumours. Methods: Retrospective, morphological case–control study, conducted on behalf of the International Dermoscopy Society. Dermatoscopic images of NM and other nodular tumours from 19 skin cancer centres worldwide were collected and analysed. Results: Overall, 254 tumours were collected (69 NM of Breslow thickness ≤2 mm, 96 NM >2 mm and 89 non-melanoma nodular lesions). Light brown coloration (50.7%) and irregular brown dots/globules (42.0%) were most frequently observed in ≤2 mm NMs. Multivariate analysis revealed that dotted vessels (3.4-fold), white shiny streaks (2.9-fold) and irregular blue structureless area (2.4-fold) were predictors for thinner NM compared to non-melanoma nodular tumours. Overall, irregular blue structureless area (3.4-fold), dotted vessels (4.6-fold) and serpentine vessels (1.9-fold) were predictors of all NM compared to non-melanoma nodular lesions. Limitations: Absence of a centralized, consensus pathology review and cases selected form tertiary centres maybe not reflecting the broader community. Conclusions: Our study sheds light into the dermatoscopic morphology of thin NM in comparison to thicker NM and could provide useful clues for its differential diagnosis from other non-melanoma nodular tumours. © 2020 European Academy of Dermatology and Venereology |
| Journal Title: | Journal of the European Academy of Dermatology and Venereology |
| Volume: | 34 |
| Issue: | 11 |
| ISSN: | 0926-9959 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2020-11-01 |
| Start Page: | 2541 |
| End Page: | 2547 |
| Language: | English |
| DOI: | 10.1111/jdv.16815 |
| PUBMED: | 32654237 |
| PROVIDER: | scopus |
| PMCID: | PMC8422943 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 January 2021 -- Source: Scopus |
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