Sentinel lymph node biopsy predicts systemic recurrence in digital papillary adenocarcinoma Journal Article

   


Authors: Bartelstein, M. K.; Schwarzkopf, E.; Busam, K. J.; Brady, M. S.; Athanasian, E. A.
Article Title: Sentinel lymph node biopsy predicts systemic recurrence in digital papillary adenocarcinoma
Abstract: Background and Objectives: Digital papillary adenocarcinoma (DPA) is a rare, aggressive neoplasm of sweat gland origin. It can recur at local, regional, or distant sites. There is limited knowledge about the role of sentinel lymph node biopsy (SLNB) in predicting recurrence in these patients. We present our experience with this uncommon tumor to evaluate the role of SLNB in predicting outcome. Methods: Medical records of all patients who underwent surgical treatment for biopsy-proven upper extremity DPA at the study institution were reviewed. Descriptive statistics and Fisher's exact test were used to analyze data. Results: Twenty-one patients were identified. Most patients were male (71%), and the median age was 51 years. SLNB was performed in 18 patients; three were positive for nodal metastatic disease (17%). At a median follow-up of 53 months, there were no local recurrences and two cases of systemic recurrence. No patient with a negative sentinel lymph node has evidence of metastasis or recurrence. Fisher's exact test demonstrated a significant association between a positive SLNB and recurrence (P =.02). Conclusion: SLNB revealed metastatic disease in 17% of patients with DPA and appears to predict systemic recurrence in this small series. © 2020 Wiley Periodicals LLC
Keywords: sentinel lymph node biopsy; sweat gland carcinoma; digital papillary adenocarcinoma
Journal Title: Journal of Surgical Oncology
Volume: 122
Issue: 7
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2020-12-01
Start Page: 1323
End Page: 1327
Language: English
DOI: 10.1002/jso.26170
PROVIDER: scopus
PUBMED: 33459374
PMCID: PMC8494386
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089398707&doi=10.1002%2fjso.26170&partnerID=40&md5=444c5095d771d6b621503dfaca8829d8
Notes: Article -- Export Date: 4 January 2021 -- Source: Scopus
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MSK Authors
  1. Edward A Athanasian
    75 Athanasian
  2. Mary Sue Brady
    203 Brady
  3. Klaus J Busam
    688 Busam
  4. Eugenia Schwarzkopf
    4 Schwarzkopf
  5. Meredith Bartelstein
    23 Bartelstein
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