CancerGenes: A gene selection resource for cancer genome projects Journal Article
| Authors: | Higgins, M. E.; Claremont, M.; Major, J. E.; Sander, C.; Lash, A. E. |
| Article Title: | CancerGenes: A gene selection resource for cancer genome projects |
| Abstract: | The genome sequence framework provided by the human genome project allows us to precisely map human genetic variations in order to study their association with disease and their direct effects on gene function. Since the description of tumor suppressor genes and oncogenes several decades ago, both germ-line variations and somatic mutations have been established to be important in cancer - in terms of risk, oncogenesis, prognosis and response to therapy. The Cancer Genome Atlas initiative proposed by the NIH is poised to elucidate the contribution of somatic mutations to cancer development and progression through the re-sequencing of a substantial fraction of the total collection of human genes - in hundreds of individual tumors and spanning several tumor types. We have developed the CancerGenes resource to simplify the process of gene selection and prioritization in large collaborative projects. CancerGenes combines gene lists annotated by experts with information from key public databases. Each gene is annotated with gene name(s), functional description, organism, chromosome number, location, Entrez Gene ID, GO terms, InterPro descriptions, gene structure, protein length, transcript count, and experimentally determined transcript control regions, as well as links to Entrez Gene, COSMIC, and iHOP gene pages and the UCSC and Ensembl genome browsers. The user-friendly interface provides for searching, sorting and intersection of gene lists. Users may view tabulated results through a web browser or may dynamically download them as a spreadsheet table. CancerGenes is available at http://cbio.mskcc.org/cancergenes. © 2007 Oxford University Press. |
| Keywords: | gene sequence; somatic mutation; mutation; cancer risk; genetic variability; computer interface; internet; user-computer interface; genetic transcription; information processing; information retrieval; carcinogenesis; cancer genetics; oncogene; tumor suppressor gene; access to information; systems integration; genomics; human genome project; bioinformatics; genome, human; gene structure; genetic database; databases, genetic; genes, neoplasm; promoter regions (genetics); web browser |
| Journal Title: | Nucleic Acids Research |
| Volume: | 35 |
| Issue: | Suppl. 1 |
| ISSN: | 0305-1048 |
| Publisher: | Oxford University Press |
| Date Published: | 2007-01-01 |
| Start Page: | D721 |
| End Page: | D726 |
| Language: | English |
| DOI: | 10.1093/nar/gkl811 |
| PUBMED: | 17088289 |
| PROVIDER: | scopus |
| PMCID: | PMC1781153 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 32" - "Export Date: 17 November 2011" - "CODEN: NARHA" - "Source: Scopus" |
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