Contrast-enhanced mammography for screening women after breast conserving surgery Journal Article


Authors: Gluskin, J.; Saccarelli, C. R.; Avendano, D.; Marino, M. A.; Bitencourt, A. G. V.; Pilewskie, M.; Sevilimedu, V.; Sung, J. S.; Pinker, K.; Jochelson, M. S.
Article Title: Contrast-enhanced mammography for screening women after breast conserving surgery
Abstract: To investigate the value of contrast-enhanced mammography (CEM) compared to full-field digital mammography (FFDM) in screening breast cancer patients after breast-conserving surgery (BCS), this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved retrospective, single-institution study included 971 CEM exams in 541 asymptomatic patients treated with BCS who underwent screening CEM between January 2013 and November 2018. Histopathology, or at least a one-year follow-up, was used as the standard of reference. Twenty-one of 541 patients (3.9%) were diagnosed with ipsi-or contralateral breast cancer: six (28.6%) cancers were seen with low-energy images (equivalent to FFDM), an additional nine (42.9%) cancers were detected only on iodine (contrast-enhanced) images, and six interval cancers were identified within 365 days of a negative screening CEM. Of the 10 ipsilateral cancers detected on CEM, four were detected on low-energy images (40%). Of the five contralateral cancers detected on CEM, two were detected on low-energy images (40%). Overall, the cancer detection rate (CDR) for CEM was 15.4/1000 (15/971), and the positive predictive value (PPV3) of the biopsies performed was 42.9% (15/35). For findings seen on low-energy images, with or without contrast, the CDR was 6.2/1000 (6/971), and the PPV3 of the biopsies performed was 37.5% (6/16). In the post-BCS screening setting, CEM has a higher CDR than FFDM. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords: breast conserving surgery; breast conservation; breast cancer screening; breast cancer recurrence; contrast enhanced mammography
Journal Title: Cancers
Volume: 12
Issue: 12
ISSN: 2072-6694
Publisher: MDPI  
Date Published: 2020-11-24
Start Page: 3495
Language: English
DOI: 10.3390/cancers12123495
PROVIDER: scopus
PMCID: PMC7760311
PUBMED: 33255412
DOI/URL:
Notes: Article -- Export Date: 4 January 2021 -- Source: Scopus
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