Identification of biological correlates associated with respiratory failure in COVID-19 Journal Article
| Authors: | Oh, J. H.; Tannenbaum, A.; Deasy, J. O. |
| Article Title: | Identification of biological correlates associated with respiratory failure in COVID-19 |
| Abstract: | Background: Coronavirus disease 2019 (COVID-19) is a global public health concern. Recently, a genome-wide association study (GWAS) was performed with participants recruited from Italy and Spain by an international consortium group. Methods: Summary GWAS statistics for 1610 patients with COVID-19 respiratory failure and 2205 controls were downloaded. In the current study, we analyzed the summary statistics with the information of loci and p-values for 8,582,968 single-nucleotide polymorphisms (SNPs), using gene ontology analysis to determine the top biological processes implicated in respiratory failure in COVID-19 patients. Results: We considered the top 708 SNPs, using a p-value cutoff of 5 × 10− 5, which were mapped to the nearest genes, leading to 144 unique genes. The list of genes was input into a curated database to conduct gene ontology and protein-protein interaction (PPI) analyses. The top ranked biological processes were wound healing, epithelial structure maintenance, muscle system processes, and cardiac-relevant biological processes with a false discovery rate < 0.05. In the PPI analysis, the largest connected network consisted of 8 genes. Through a literature search, 7 out of the 8 gene products were found to be implicated in both pulmonary and cardiac diseases. Conclusion: Gene ontology and PPI analyses identified cardio-pulmonary processes that may partially explain the risk of respiratory failure in COVID-19 patients. © 2020, The Author(s). |
| Keywords: | genome-wide association study; bioinformatics; respiratory failure; single-nucleotide polymorphisms; covid-19; sars-cov-2 |
| Journal Title: | BMC Medical Genomics |
| Volume: | 13 |
| ISSN: | 1755-8794 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2020-12-11 |
| Start Page: | 186 |
| Language: | English |
| DOI: | 10.1186/s12920-020-00839-1 |
| PUBMED: | 33308225 |
| PROVIDER: | scopus |
| PMCID: | PMC7729705 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 4 January 2021 -- Source: Scopus |
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