Use of herpes simplex virus thymidine kinase gene as the suicide gene in gene therapy protocols Journal Article

  


Authors: Likar, Y. N.; Moroz, M. A.; Rumyantsev, A. G.
Article Title: Use of herpes simplex virus thymidine kinase gene as the suicide gene in gene therapy protocols
Abstract: Gene therapy using suicide genes is now being adapted to clinical use. This method is based on the use of genes, whose expression under certain conditions leads to the death of cells transfected by them. This technology has been amply studied from the middle to the end of the 1990ies and described in numerous papers. During the recent decade studies of suicide gene therapy progressed from experimental to clinical studies on an extensive population of patients with malignant tumors. Today the studies are focused on search for more effective and safe approaches to the use of this method. The first example of effective use of the method in experimental and clinical oncology is delivery of herpes simplex virus thymidine kinase type 1 (HSV1-tk) gene into tumor cells with subsequent ganciclovir treatment, leading to their death. © 2009, Fund - Doctors, Innovations,Science for Children. All rights reserved.
Keywords: ganciclovir; suicide gene; suicide gene therapy; herpes simplex virus type 1 thymidine kinase (hsv1-tk)
Journal Title: Pediatric Hematology/Oncology and Immunopathology
Volume: 8
Issue: 2
ISSN: 1726-1708
Publisher: Izdatel'stvo Dinastiya  
Date Published: 2009-01-01
Start Page: 31
End Page: 35
Language: Russian
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096534279&partnerID=40&md5=b1737496176878a7b86f46eaa234c263
Notes: Article -- Export Date: 4 January 2021 -- Source: Scopus