A phase I trial of BMS-247550 (NSC# 710428) and gemcitabine in patients with advanced solid tumors Journal Article
| Authors: | Hensley, M. L.; Dizon, D.; Derosa, F.; Venkatraman, E.; Sabbatini, P.; Chi, D. S.; Dupont, J.; Colevas, A. D.; Spriggs, D.; Aghajanian, C. |
| Article Title: | A phase I trial of BMS-247550 (NSC# 710428) and gemcitabine in patients with advanced solid tumors |
| Abstract: | The purpose of this study is to establish the maximum tolerated dose and define the dose-limiting toxicity of the investigational epothilone BMS-247550 in combination with fixed dose-rate gemcitabine. Patients with advanced, recurrent solid tumors who had received ≤2 prior cytotoxic regimens for recurrent disease were treated with gemcitabine over 90 min on days 1 and 8 plus BMS-247550 over 3 h on day 8, every 21 days in a phase I study. Dose-limiting toxicity definitions were based on severe myelosuppression, or grade 3 or 4 treatment-related non-hematologic toxicity, or dose delay of greater than 2 weeks due to treatment toxicity observed in the first treatment cycle. Dose cohort 1 received gemcitabine 900 mg/m2 and BMS-247550 20 mg/m 2. Grade 4 neutropenia lasting ≥7 days occurred in one of six patients. Two of three patients in cohort 2 (gemcitabine 900 mg/m2 plus BMS-247550 30 mg/m2) had dose-limiting toxicities of grade 4 neutropenia. An additional three patients were treated at dose level 1 with no additional dose-limiting toxicities observed. At an intermediate dose level (gemcitabine 750 mg/m2 plus BMS-247550 30 mg/m2), two of six patients experienced a dose-limiting toxicity (febrile neutropenia and grade 3 hypophosphatemia in 1, grade 3 hypophosphatemia and grade 3 hyponatremia in (1), and five of six patients experienced dose delays. In the final cohort (gemcitabine 750 mg/m2 plus BMS-247550 25 mg/m2), two of two patients experienced a dose-limiting toxicity. Treatment-related toxicites included neutropenia, thrombocytopenia, neutropenic fever, hypophosphotemia, and hyponatremia. Nine of 14 patients evaluable for response had stable disease. The maximum tolerated dose for this schedule is gemcitabine 900 mg/m2 over 90 min days 1 and 8 plus BMS-247550 20 mg/m2 on day 8. Attempts to increase the dose of BMS-247550 by decreasing the gemcitabine dose did not sufficiently ameliorate myelosuppression. Stable disease was observed in some patients with prior taxane exposure. © 2007 Springer Science+Business Media, LLC. |
| Keywords: | adult; clinical article; aged; middle aged; clinical trial; drug tolerability; fatigue; hypophosphatemia; solid tumor; gemcitabine; endometrium cancer; neoplasms; ovarian neoplasms; melanoma; ovary cancer; cohort studies; bone marrow suppression; leukopenia; nausea; thrombocytopenia; antineoplastic combined chemotherapy protocols; lung neoplasms; dose-response relationship, drug; urinary bladder neoplasms; kidney neoplasms; drug hypersensitivity; febrile neutropenia; fever; lymphocytopenia; sarcoma; hypokalemia; hyponatremia; lung small cell cancer; tumor recurrence; thrombosis; drug response; phase 1 clinical trial; taxane derivative; kidney cancer; deoxycytidine; uterine neoplasms; uterus sarcoma; drug exposure; solid tumors; ixabepilone; epothilones; epothilone; carcinoma, small cell; diphenhydramine; dose; ranitidine; phase i study; water-electrolyte imbalance |
| Journal Title: | Investigational New Drugs |
| Volume: | 25 |
| Issue: | 4 |
| ISSN: | 0167-6997 |
| Publisher: | Springer |
| Date Published: | 2007-08-01 |
| Start Page: | 335 |
| End Page: | 341 |
| Language: | English |
| DOI: | 10.1007/s10637-007-9035-x |
| PUBMED: | 17364235 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 17 November 2011" - "CODEN: INNDD" - "Source: Scopus" |
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