Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia Journal Article
| Authors: | Goebel, S. J.; Taylor, J.; Barr, B. C.; Kiehn, T. E.; Castro-Malaspina, H. R.; Hedvat, C. V.; Rush-Wilson, K. A.; Kelly, C. D.; Davis, S. W.; Samsonoff, W. A.; Hurst, K. R.; Behr, M. J.; Masters, P. S. |
| Article Title: | Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia |
| Abstract: | An unknown virus was isolated from a lung biopsy sample and multiple other samples from a patient who developed a lethal case of pneumonia following a peripheral blood stem cell transplant. A random PCR-based molecular screening method was used to identify the infectious agent as avian paramyxovirus 1 (APMV-1; a group encompassing Newcastle disease virus), which is a highly contagious poultry pathogen that has only rarely been found in human infections. Immunohistochemical analysis confirmed the presence of APMV-1 antigen in sloughed alveolar cells in lung tissue from autopsy. Sequence from the human isolate showed that it was most closely related to virulent pigeon strains of APMV-1. This is the most completely documented case of a systemic human infection caused by APMV-1 and is the first report of an association between this virus and a fatal disease in a human. Copyright © 2007, American Society for Microbiology. All Rights Reserved. |
| Keywords: | immunohistochemistry; adult; controlled study; human tissue; human cell; nonhuman; polymerase chain reaction; animals; stem cell transplantation; molecular sequence data; nucleotide sequence; autopsy; screening test; fatal outcome; peripheral blood stem cell transplantation; lung biopsy; virus strain; virus pneumonia; lethality; virus isolation; fatality; newcastle disease virus; newcastle disease paramyxovirus; virus virulence; lung parenchyma; poultry; antigens, viral; avulavirus; newcastle disease; lung alveolus cell; avian paramyxovirus 1; pneumonia, viral; apple mosaic virus; columba |
| Journal Title: | Journal of Virology |
| Volume: | 81 |
| Issue: | 22 |
| ISSN: | 0022-538X |
| Publisher: | American Society for Microbiology |
| Date Published: | 2007-11-01 |
| Start Page: | 12709 |
| End Page: | 12714 |
| Language: | English |
| DOI: | 10.1128/jvi.01406-07 |
| PUBMED: | 17855523 |
| PROVIDER: | scopus |
| PMCID: | PMC2168997 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "CODEN: JOVIA" - "Molecular Sequence Numbers: GENBANK: AJ415883, AJ880277, AY288995, AY288996, AY505068, EF555090, EF555091, EF555092, EF555093, EF555094, EF555095, EF555096;" - "Source: Scopus" |
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126Hedvat -
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333Castro-Malaspina
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