Targeting integrin β4 for cancer and anti-angiogenic therapy Journal Article
| Author: | Giancotti, F. G. |
| Article Title: | Targeting integrin β4 for cancer and anti-angiogenic therapy |
| Abstract: | The integrins play key roles in the signaling networks that drive pathological angiogenesis and tumor progression. Integrin β4 is a laminin receptor upregulated in tumor cells and angiogenic endothelial cells. Biochemical studies have indicated that β4 combines with and enhances the signaling function of multiple receptor tyrosine kinases, including ErbB2, EGF-R and Met. Genetic studies have revealed that β4 signaling promotes both angiogenesis and tumorigenesis. Here, I discuss the hypothesis that β4 promotes both processes by amplifying receptor-tyrosine-kinase signaling. Therefore, I propose that a simultaneous blockade of β4 and receptor-tyrosine-kinase signaling represents a rational approach to cancer and anti-angiogenic therapy. © 2007 Elsevier Ltd. All rights reserved. |
| Keywords: | signal transduction; vascular endothelial growth factor a; unclassified drug; oncoprotein; proto-oncogene proteins; review; angiogenesis inhibitor; nonhuman; antineoplastic agents; drug targeting; antineoplastic agent; genetic analysis; animal; cytology; animals; breast cancer; protein targeting; epidermal growth factor receptor; epidermal growth factor receptor 2; receptor, epidermal growth factor; drug effect; protein tyrosine kinase; angiogenesis; cancer therapy; physiology; drug antagonism; vasculotropin a; receptor, erbb-2; upregulation; trastuzumab; angiogenesis inhibitors; biochemistry; beta adrenergic receptor blocking agent; epidermal growth factor receptor kinase inhibitor; beta4 integrin; integrin beta4; receptors, growth factor; hypothesis; erbb2 protein, human; growth factor receptor; small molecule transport agent; met protein, human |
| Journal Title: | Trends in Pharmacological Sciences |
| Volume: | 28 |
| Issue: | 10 |
| ISSN: | 0165-6147 |
| Publisher: | Cell Press |
| Date Published: | 2007-10-01 |
| Start Page: | 506 |
| End Page: | 511 |
| Language: | English |
| DOI: | 10.1016/j.tips.2007.08.004 |
| PUBMED: | 17822782 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 24" - "Export Date: 17 November 2011" - "CODEN: TPHSD" - "Source: Scopus" |
