Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines Journal Article
| Authors: | Galonić, D. P.; Gin, D. Y. |
| Article Title: | Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines |
| Abstract: | Therapeutic vaccines derived from carbohydrate antigen-adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the complex oligosaccharide constructs that are needed for the systematic design and evaluation of novel vaccine formulations relies on de novo chemical synthesis. The use of both state-of-the-art and emerging glycosylation technologies has led to significant advances in this field, allowing the clinical exploration of carbohydrate-based antigens in the treatment of cancer. ©2007 Nature Publishing Group. |
| Keywords: | unclassified drug; review; nonhuman; drug targeting; animals; cancer immunotherapy; drug screening; drug design; drug synthesis; structure activity relation; tumor antigen; molecular sequence data; antigen; antigens, neoplasm; cancer vaccines; ganglioside gd2; antigen detection; breast tumor; ovary tumor; prostate tumor; glycosylation; immunological adjuvant; adjuvants, immunologic; epithelium tumor; oxidation; drug conjugation; ganglioside gd3; ganglioside gm2; vaccine; carbohydrate analysis; carbohydrate sequence; carbohydrate antigen; glycan derivative; carbohydrate; drug formulation; carbohydrate derivative; glycosphingolipid; cancer antibody; glycoconjugate; glycoside; ganglioside; acetal; globo h hexasaccharide; mucin associated glycan; qs 21a; chemosynthesis; acetalization; carbohydrate synthesis; glycoconjugates |
| Journal Title: | Nature |
| Volume: | 446 |
| Issue: | 7139 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2007-04-26 |
| Start Page: | 1000 |
| End Page: | 1007 |
| Language: | English |
| DOI: | 10.1038/nature05813 |
| PUBMED: | 17460660 |
| PROVIDER: | scopus |
| PMCID: | PMC2631661 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 87" - "Export Date: 17 November 2011" - "CODEN: NATUA" - "Source: Scopus" |
