Modeling leukemia stem cells with patient-derived induced pluripotent stem cells Journal Article

   


Authors: Deslauriers, A. G.; Kotini, A. G.; Papapetrou, E. P.
Article Title: Modeling leukemia stem cells with patient-derived induced pluripotent stem cells
Abstract: Patient-derived induced pluripotent stem cells (iPSCs) have recently provided a new way to model acute myeloid leukemia (AML) and other myeloid malignancies. Here, we describe methods for the generation of patient-derived iPSCs from leukemia cells and for their subsequent directed in vitro differentiation into hematopoietic cells that recapitulate features of leukemia stem cells (LSCs) and leukemic blasts. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords: reprogramming; aml; human induced pluripotent stem cells; ipsc disease modeling; hpsc-hematopoiesis
Journal Title: Methods in Molecular Biology
Volume: 2185
ISSN: 1064-3745
Publisher: Humana Press Inc  
Date Published: 2021-01-01
Start Page: 411
End Page: 422
Language: English
DOI: 10.1007/978-1-0716-0810-4_26
PUBMED: 33165864
PROVIDER: scopus
PMCID: PMC7821974
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85095978843&doi=10.1007%2f978-1-0716-0810-4_26&partnerID=40&md5=6d44af89c9979232427c2a8a1a342185
Notes: Book Chapter 26 in Cobaleda C, Sánchez-García I, eds. Leukemia Stem Cells: Methods and Protocols (ISBN 978-1-0716-0809-8) -- Export Date: 1 December 2020 -- Source: Scopus
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  1. Andre Deslauriers
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