Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites Journal Article

   


Authors: Guo, H.; Chou, W. C.; Lai, Y.; Liang, K.; Tam, J. W.; Brickey, W. J.; Chen, L.; Montgomery, N. D.; Li, X.; Bohannon, L. M.; Sung, A. D.; Chao, N. J.; Peled, J. U.; Gomes, A. L. C.; van den Brink, M. R. M.; French, M. J.; Macintyre, A. N.; Sempowski, G. D.; Tan, X.; Sartor, R. B.; Lu, K.; Ting, J. P. Y.
Article Title: Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites
Abstract: Ionizing radiation causes acute radiation syndrome, which leads to hematopoietic, gastrointestinal, and cerebrovascular injuries. We investigated a population of mice that recovered from high-dose radiation to live normal life spans. These "elite-survivors" harbored distinct gut microbiota that developed after radiation and protected against radiation-induced damage and death in both germ-free and conventionally housed recipients. Elevated abundances of members of the bacterial taxa Lachnospiraceae and Enterococcaceae were associated with postradiation restoration of hematopoiesis and gastrointestinal repair. These bacteria were also found to be more abundant in leukemia patients undergoing radiotherapy, who also displayed milder gastrointestinal dysfunction. In our study in mice, metabolomics revealed increased fecal concentrations of microbially derived propionate and tryptophan metabolites in elite-survivors. The administration of these metabolites caused long-term radioprotection, mitigation of hematopoietic and gastrointestinal syndromes, and a reduction in proinflammatory responses. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Journal Title: Science
Volume: 370
Issue: 6516
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 2020-10-30
Start Page: eaay9097
Language: English
DOI: 10.1126/science.aay9097
PUBMED: 33122357
PROVIDER: scopus
PMCID: PMC7898465
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094935670&doi=10.1126%2fscience.aay9097&partnerID=40&md5=a19c7ec5bd9a7a1a3872bc962d26d0bf
Notes: Article -- Export Date: 1 December 2020 -- Source: Scopus
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Jonathan U Peled
    154 Peled
  3. Antonio LC Gomes
    47 Gomes
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