Radiotherapy and late effects Review
| Authors: | Palmer, J. D.; Hall, M. D.; Mahajan, A.; Paulino, A. C.; Wolden, S.; Constine, L. S. |
| Review Title: | Radiotherapy and late effects |
| Abstract: | Advances in multimodality care for patients with pediatric cancer continues to improve long-term survival. The use of surgery, chemotherapy, and radiotherapy may lead to debilitating late effects in childhood cancer survivors. It is critically important to understand, mitigate, and screen for late effects to improve the quality of life in childhood cancer survivors. This review summarizes the use of radiotherapy in children, radiobiology of tissue injury, impact of age on late effects, important organ systems affected by radiotherapy during survivorship, and screening for radiotherapy late effects. © 2020 Elsevier Inc. |
| Keywords: | busulfan; review; intensity modulated radiation therapy; cisplatin; doxorubicin; cancer radiotherapy; methotrexate; carboplatin; lung disease; radiotherapy; cyclophosphamide; radiation injury; carmustine; ifosfamide; lomustine; childhood cancer; radiation exposure; late effects; dna; biological activity; radiation dose fractionation; cardiovascular disease; dactinomycin; brachytherapy; bleomycin; corticosteroid derivative; cataract; double stranded dna break; liver disease; dyslipidemia; platinum derivative; osteoporosis; stereotactic radiosurgery; eye disease; heart arrhythmia; anthracycline derivative; anthracycline; urogenital tract disease; antineoplastic antimetabolite; lung fibrosis; gastrointestinal disease; renovascular hypertension; hemorrhagic cystitis; hearing impairment; musculoskeletal disease; endocrine disease; tioguanine; cardiomyopathy; heart muscle conduction disturbance; mercaptopurine; radiobiology; central nervous system disease; osteopenia; conformal radiotherapy; pediatric cancer; kidney dysfunction; proton therapy; bladder dysfunction; ear disease; anthraquinone; urinary tract disease; neuroendocrine disease; digestive system disease; planning target volume; human; disorders of higher cerebral function |
| Journal Title: | Pediatric Clinics of North America |
| Volume: | 67 |
| Issue: | 6 |
| ISSN: | 0031-3955 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2020-12-01 |
| Start Page: | 1051 |
| End Page: | 1067 |
| Language: | English |
| DOI: | 10.1016/j.pcl.2020.08.001 |
| PUBMED: | 33131534 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 December 2020 -- Source: Scopus |
