Authors: | Caeser, R.; Sen, T. |
Title: | Should WEE(1) CHK(1) in on the FAM(122A)ily? |
Abstract: | Li et al. (2020) elucidate the resistance mechanisms to small-molecule inhibitors targeting the G2/M cell cycle checkpoint kinase, CHK1, in a variety of non-small cell lung cancer cell lines using CRISPR-mediated genetic approaches and identify biomarkers of response. © 2020 Elsevier Inc. Li et al. (2020) elucidate the resistance mechanisms to small-molecule inhibitors targeting G2-M cell cycle checkpoint kinase, CHK1, in a variety of non-small cell lung cancer (NSCLC) cell lines using CRISPR-mediated genetic approaches and identify biomarkers of response. © 2020 Elsevier Inc. |
Keywords: | genetics; cell cycle protein; metabolism; cell cycle proteins; protein kinases; carcinoma, non-small-cell lung; lung neoplasms; cell line, tumor; phosphorylation; lung tumor; tumor cell line; checkpoint kinase 1; protein kinase; non small cell lung cancer; humans; human |
Journal Title: | Molecular Cell |
Volume: | 80 |
Issue: | 3 |
ISSN: | 1097-2765 |
Publisher: | Cell Press |
Date Published: | 2020-11-05 |
Start Page: | 377 |
End Page: | 378 |
Language: | English |
DOI: | 10.1016/j.molcel.2020.10.011 |
PUBMED: | 33157011 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Article -- Export Date: 1 December 2020 -- Source: Scopus |