Immune checkpoint inhibitor–associated diabetes: A single-institution experience Journal Article
| Authors: | Byun, D. J.; Braunstein, R.; Flynn, J.; Zheng, J.; Lefkowitz, R. A.; Kanbour, S.; Girotra, M. |
| Article Title: | Immune checkpoint inhibitor–associated diabetes: A single-institution experience |
| Abstract: | OBJECTIVE To characterize immune checkpoint inhibitor–associated diabetes mellitus (ICI-DM) in a single-institution case series. RESEARCH DESIGN AND METHODS Retrospective chart review of 18 patients with new-onset ICI-DM following anti– programmed cell death protein 1 (PD-1)/anti–programmed cell death protein ligand 1 (PD-L1) therapy for advanced carcinomas. RESULTS Of 18 patients, 9 had diabetic ketoacidosis (median glucose 27.92 mmol/L; median glucose before presentation 6.35 mmol/L). Median C-peptide at ICI-DM diagnosis was low, and it declined during follow-up. Median anti-PD-1/anti-PD-L1 duration before ICI-DM was 3.65 months (range 0.56–12.23 months). Time to ICI-DM onset was a median 1.4 months/3 ICI cycles and 6 months/10 cycles in those patients who were positive and negative for GAD65 autoantibodies, respectively. Time to ICI-DM onset was a median 2.5 months/3 ICI cycles and 4.8 months/8 cycles after anti-PD-L1 or anti-PD-1 therapy, respectively. Significant pancreatic atrophy was seen radiographically. CONCLUSIONS ICI-DM presents abruptly, appears irreversible, is characterized by pancreatic atrophy, and may occur both earlier following PD-L1 blockade compared with PD-1 inhibition and in those who have positive GAD65 autoantibodies. © 2020 by the American Diabetes Association. |
| Journal Title: | Diabetes Care |
| Volume: | 43 |
| Issue: | 12 |
| ISSN: | 0149-5992 |
| Publisher: | American Diabetes Association |
| Date Published: | 2020-12-01 |
| Start Page: | 3106 |
| End Page: | 3109 |
| Language: | English |
| DOI: | 10.2337/dc20-0609 |
| PUBMED: | 33051330 |
| PROVIDER: | scopus |
| PMCID: | PMC7770268 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2020 -- Source: Scopus |
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