Human norepinephrine transporter gene is a target for visualization of oncological diseases at the molecular level Journal Article
| Authors: | Moroz, M. A.; Likar, Y. N.; Dubrovin, M. M.; Rumyantsev, A. G. |
| Article Title: | Human norepinephrine transporter gene is a target for visualization of oncological diseases at the molecular level |
| Abstract: | The expression of norepinephrine transporter (NET) in humans is virtually completely confined to the central and peripheral sympathetic nervous system. Due to this fact, it was suggested to use the NET gene as the target gene in complex of molecular imaging methods. An important part of noninvasive molecular imaging in general and of using reporter gene in particular is nuclear imaging, based on the use of samples labeled by various isotopes. One of the most up-to-date approaches to the use of human NET in nuclear imaging is the use of124I-labeled metaiodobenzylguanidine sample, fit for positron emission tomogra-phy (PET), one of the most sensitive methods in radiology. This method was developed at the Memorial Sloan-Kettering Cancer Center, New York, USA. Isolated natural expression and human origin of NET, determining its specificity and immunoreactivi-ty, suggest clinical use of human NET as a reporter gene for PET imaging of tumors, developing from nervous tissue precur-sors (neuroblastoma, pheochromocytoma) and in cell and, presumably, gene therapies. © 2009, Fund - Doctors, Innovations,Science for Children. All rights reserved. |
| Keywords: | positron emission tomography; molecular imaging; metaiodobenzylguanidine; 124i; human norepinephrine transporter |
| Journal Title: | Pediatric Hematology/Oncology and Immunopathology |
| Volume: | 8 |
| Issue: | 2 |
| ISSN: | 1726-1708 |
| Publisher: | Izdatel'stvo Dinastiya |
| Date Published: | 2009-01-01 |
| Start Page: | 36 |
| End Page: | 40 |
| Language: | Russian |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2020 -- Source: Scopus |
MSK Authors
-
30Moroz
Related MSK Work