Prospective evaluation of p53 as a prognostic marker in T1 transitional cell carcinoma of the bladder Journal Article
| Authors: | Dalbagni, G.; Parekh, D. J.; Ben-Porat, L.; Potenzoni, M.; Herr, H. W.; Reuter, V. E. |
| Article Title: | Prospective evaluation of p53 as a prognostic marker in T1 transitional cell carcinoma of the bladder |
| Abstract: | OBJECTIVE: To prospectively evaluate p53 overexpression as a predictor of survival in patients with a first diagnosis of T1 transitional cell carcinoma (TCC) of the bladder, as several reports implicate p53 as an important prognostic marker for progression and survival, but all previous studies were retrospective, giving conflicting and irreproducible results, rendering inappropriate any attempt at integrating p53 into clinical decision-making. PATIENTS AND METHODS: Patients with a first diagnosis of T1 TCC of the bladder were enrolled; p53 overexpression was assessed by immunohistochemistry (IHC) using both monoclonal antibody 1801 and DO7. The pathological stage and IHC score were assigned by one pathologist, and the markers were scored categorically. RESULTS: Of the 89 patients who were evaluable, 53 had p53-positive tumours. The median follow-up for the survivors was 52 months. Eighty-two patients had high-grade tumours, using the World Health Organisation/International Society of Urological Pathology 1998 grading system. Fifty-eight patients had unifocal tumours and 34 had associated carcinoma in situ. During the follow-up, 34 additional patients had a radical cystectomy and nine died from bladder cancer. The association of p53 overexpression with progression or survival was not significant. CONCLUSIONS: p53 tissue typing by IHC in a prospective cohort of patients with T1 bladder cancer was not clinically useful as a prognostic marker in a contemporary series of T1 tumours. © 2006 The Authors. |
| Keywords: | immunohistochemistry; survival; adult; cancer survival; controlled study; human tissue; aged; aged, 80 and over; middle aged; cancer surgery; survival rate; major clinical study; cancer growth; united states; disease marker; follow up; follow-up studies; prospective study; prospective studies; gene overexpression; cohort studies; tumor markers, biological; cohort analysis; bladder cancer; protein p53; tumor marker; prediction; urinary bladder neoplasms; cancer survivor; monoclonal antibody; disease severity; disease progression; carcinoma in situ; cystectomy; scoring system; tumor suppressor protein p53; carcinoma, transitional cell; bladder carcinoma; transitional cell carcinoma; p53; markers; t1; tissue typing |
| Journal Title: | BJU International |
| Volume: | 99 |
| Issue: | 2 |
| ISSN: | 1464-4096 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2007-02-01 |
| Start Page: | 281 |
| End Page: | 285 |
| Language: | English |
| DOI: | 10.1111/j.1464-410X.2006.06624.x |
| PUBMED: | 17155984 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 19" - "Export Date: 17 November 2011" - "CODEN: BJINF" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work