Optical coherence tomography characteristics of the choroid underlying congenital hypertrophy of the retinal pigment epithelium Journal Article
| Authors: | Francis, J. H.; Sobol, E. K.; Greenberg, M.; Folberg, R.; Abramson, D. H. |
| Article Title: | Optical coherence tomography characteristics of the choroid underlying congenital hypertrophy of the retinal pigment epithelium |
| Abstract: | Purpose: This study evaluates and characterizes the choroid underlying congenital hypertrophy of the retinal pigment epithelium (CHRPE). Methods: Retrospective observational study of CHRPE at least 2 mm in diameter. Choroidal vascular architecture was qualitatively examined. Choroidal thickness was measured by 2 independent observers using enhanced depth imaging spectral domain optical coherence tomography. Results: Forty-six eyes of 46 patients with CHRPE were included. Thirty-two lesions had imaging sufficient for analysis. Haller's layer was healthy in 18 (56%), thin in 13 (41%), and absent in 1 (2%). Sattler's layer was atrophic in 30 (94%), and choriocapillaris was atrophic in 31 (97%). CHRPE with thinned Haller's layer had significantly larger diameter. The mean sub-CHRPE choroidal thickness was 82.4 ± 7.9 μm, compared to a thickness of 148.4 ± 9.6 μm in the normal adjacent choroid (p < 0.0001). Mean retinal thickness overlying the CHRPE was 77.3 ± 4.3 μm, compared to a retinal thickness of 137.8 ± 2.9 μm overlying the normal adjacent choroid (p < 0.0001). Sub-CHRPE choroidal thickness was a mean of 56.2 ± 3.1% of the adjacent normal choroidal thickness. Conclusion: The underlying choroid CHRPE is thinner than the adjacent normal choroid. All layers of the choroid can be thin with a preference of the inner Sattler's and choriocapillaris layers. © 2020 S. Karger AG. All rights reserved. |
| Journal Title: | Ocular Oncology and Pathology |
| Volume: | 6 |
| Issue: | 4 |
| ISSN: | 2296-4681 |
| Publisher: | Karger |
| Date Published: | 2020-08-01 |
| Start Page: | 238 |
| End Page: | 243 |
| Language: | English |
| DOI: | 10.1159/000504712 |
| PROVIDER: | scopus |
| PMCID: | PMC7506233 |
| PUBMED: | 33005612 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 November 2020 -- Source: Scopus |
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