Patterns of first-recurrence and post-recurrence survival in patients with primary cutaneous melanoma after sentinel lymph node biopsy Journal Article

  

Authors:	Dalal, K. M.; Patel, A.; Brady, M. S.; Jaques, D. P.; Coit, D. G.
Article Title:	Patterns of first-recurrence and post-recurrence survival in patients with primary cutaneous melanoma after sentinel lymph node biopsy
Abstract:	Background: Sentinel lymph node biopsy (SLNB) has become well accepted in management of patients with primary cutaneous melanoma. An understanding of the pattern of recurrence after SLNB is helpful in coordinating a rational plan of follow-up in these patients. We sought to determine the site and timing of initial recurrence and post-recurrence survival after SLNB. Methods: Stage I/II melanoma patients who underwent SLNB during 1991-2004 were identified from a prospective single-institution database. Site and date of first recurrence after SLNB were recorded. Patterns of recurrence after SLNB and post-recurrence survival were analyzed. Results: One thousand and forty-six patients underwent SLNB. The sentinel lymph node (SLN) was positive in 164 patients (16%). Median follow-up was 36 months for survivors. Median and 3-year relapse-free survival for SLN-positive patients were 41 months and 56%, and for SLN-negative patients were not reached and 87%, respectively (P < .0001). Of the SLN-positive patients, 47% experienced recurrence, compared with 14% SLN-negative patients. The pattern of recurrence stratified by SLN status was similar between the two groups (P = NS). After recurrence, the site of recurrence was the only significant prognostic factor influencing survival (P < .0001). Conclusions: Although SLN-positive patients experience recurrence far earlier and more frequently than SLN-negative patients, the pattern of recurrence is similar. After recurrence, its site is the primary determinant of survival. © 2007 Society of Surgical Oncology.
Keywords:	adolescent; adult; cancer survival; child; controlled study; human tissue; aged; aged, 80 and over; disease-free survival; middle aged; survival rate; retrospective studies; major clinical study; cancer recurrence; recurrence risk; recurrent cancer; follow up; follow-up studies; neoplasm staging; prospective studies; sentinel lymph node biopsy; melanoma; neoplasm recurrence, local; skin neoplasms; recurrence; age factors; time; time factors; cancer survivor; cancer relapse; post-recurrence survival
Journal Title:	Annals of Surgical Oncology
Volume:	14
Issue:	6
ISSN:	1068-9265
Publisher:	Springer
Date Published:	2007-06-01
Start Page:	1934
End Page:	1942
Language:	English
DOI:	10.1245/s10434-007-9357-0
PUBMED:	17406951
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-34249872438&partnerID=40&md5=bede3a6a11e226b15646c355b63f34e6
Notes:	--- - "Cited By (since 1996): 12" - "Export Date: 17 November 2011" - "CODEN: ASONF" - "Source: Scopus"

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