Invasive stratified mucinous carcinoma (iSMC) of the cervix often presents with high-risk features that are determinants of poor outcome: An international multicenter study Journal Article

   

Authors:	Stolnicu, S.; Boros, M.; Segura, S.; Horn, L. C.; Parra-Herran, C.; Oliva, E.; Abu-Rustum, N.; Soslow, R. A.; Park, K. J.
Article Title:	Invasive stratified mucinous carcinoma (iSMC) of the cervix often presents with high-risk features that are determinants of poor outcome: An international multicenter study
Abstract:	Invasive stratified mucinous carcinoma (iSMC) has been suggested to represent an aggressive subtype of endocervical adenocarcinoma. We sought to investigate the outcomes of iSMC and determine which clinical and pathologic parameters may influence the prognosis. Slides from 52 cases of iSMC were collected and classified as follows: pure iSMC (>90% of the entire tumor) and iSMC mixed with other human papillomavirus-associated adenocarcinoma components (miSMC) (>10%, but <90% of the entire tumor). Clinical and pathologic parameters were evaluated and compared with overall survival (OS) and recurrence-free survival (RFS). One third of patients with iSMC presented with lymph node metastases (LNM) and 25% developed local recurrences, whereas 4 (7.7%) developed distant recurrences. 29 cases (55.8%) were pure iSMC, whereas 23 cases (44.23%) were miSMC. OS was 74.7% in pure iSMC versus 85.2% in miSMC (P=0.287). RFS was 56.5% in pure iSMC and 72.9% in miSMC (P=0.185). At 5 years, OS in stage I was 88.9% versus stage II to IV 30% (P=0.004), whereas RFS in stage I was 73.9% versus stage II to IV 38.1% (P=0.02). OS was influenced by International Federation of Gynecology and Obstetrics (FIGO) stage (P=0.013), tumor size (P=0.02), LNM (P=0.015), and local recurrence (P=0.022), whereas RFS was influenced by FIGO stage (P=0.031), tumor size (P=0.001), local recurrence (P=0.009), LNM (P=0.008), and type of surgical treatment (P=0.044). iSMC is an aggressive cervical tumor biologically different from other human papillomavirus-associated adenocarcinomas due to the propensity for LNM, local/distant recurrence. FIGO stage, tumor size, LNM, and presence of local/pelvic recurrences are determinants of outcome in iSMCs. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Keywords:	recurrence; prognostic factors; outcome; invasive stratified mucin-producing carcinoma; ismc
Journal Title:	American Journal of Surgical Pathology
Volume:	44
Issue:	10
ISSN:	0147-5185
Publisher:	Lippincott Williams & Wilkins
Date Published:	2020-10-01
Start Page:	1374
End Page:	1380
Language:	English
DOI:	10.1097/pas.0000000000001485
PUBMED:	32271191
PROVIDER:	scopus
PMCID:	PMC7492372
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083548544&doi=10.1097%2fPAS.0000000000001485&partnerID=40&md5=abe7c5fa4c49419801a050546ce48aaa
Notes:	Article -- Export Date: 2 November 2020 -- Source: Scopus

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