Use of the Oncotype DX™ 21-gene assay to guide adjuvant decision making in early-stage breast cancer Journal Article
| Authors: | Conlin, A. K.; Seidman, A. D. |
| Article Title: | Use of the Oncotype DX™ 21-gene assay to guide adjuvant decision making in early-stage breast cancer |
| Abstract: | The decision to use adjuvant chemotherapy in patients with early stage breast cancer involves the consideration of many factors that traditionally rely heavily on tumor size and lymph node involvement and a limited set of biologic characteristics such as estrogen receptor and HER2 expression. Overtreatment with cytotoxic chemotherapy is a significant concern among patients and physicians. Using the currently accepted guidelines it has been estimated that a large percentage of patients receiving chemotherapy for low-risk breast cancers may be overtreated. Gene expression profiling is a new technology being developed to help improve risk stratification of patients and to predict outcomes. The Oncotype DX™ assay is one example of a gene expression profile validated in women with lymph node-negative, estrogen receptor-expressing breast cancer. This assay and others aim to help improve risk classification and recurrence prediction and, therefore, optimize selection of patients for adjuvant chemotherapy. © 2007 Adis Data Information BV. All rights reserved. |
| Keywords: | cancer chemotherapy; cancer survival; protein expression; genetics; review; doxorubicin; fluorouracil; adjuvant therapy; chemotherapy, adjuvant; methotrexate; cancer staging; methodology; antineoplastic agent; lymph nodes; biomarkers; metabolism; breast cancer; gene expression profiling; tumor volume; epidermal growth factor receptor 2; cyclophosphamide; pathology; breast neoplasms; docetaxel; gene expression regulation; gene expression regulation, neoplastic; adjuvant chemotherapy; breast tumor; lymph node; tamoxifen; genomics; clinical decision making; receptors, estrogen; pharmacogenetics; estrogen receptor; breast cancer, general; diagnostic tests; early breast cancer; estrogen receptor expression |
| Journal Title: | Molecular Diagnosis and Therapy |
| Volume: | 11 |
| Issue: | 6 |
| ISSN: | 1177-1062 |
| Publisher: | Adis Data Information Bv |
| Date Published: | 2007-01-01 |
| Start Page: | 355 |
| End Page: | 360 |
| Language: | English |
| PUBMED: | 18078353 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "Source: Scopus" |
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