Prospective study of the correlation between postoperative computed tomography scan and primary surgeon assessment in patients with advanced ovarian, tubal, and peritoneal carcinoma reported to have undergone primary surgical cytoreduction to residual disease 1 cm or less Journal Article


Authors: Chi, D. S.; Ramirez, P. T.; Teitcher, J. B.; Mironov, S.; Sarasohn, D. M.; Iyer, R. B.; Eisenhauer, E. L.; Abu-Rustum, N. R.; Sonoda, Y.; Levine, D. A.; Brown, C. L.; Aghajanian, C.; Gershenson, D. M.; Hoskins, W. J.; Hricak, H.; Barakat, R. R.
Article Title: Prospective study of the correlation between postoperative computed tomography scan and primary surgeon assessment in patients with advanced ovarian, tubal, and peritoneal carcinoma reported to have undergone primary surgical cytoreduction to residual disease 1 cm or less
Abstract: Purpose: To compare surgeons' operative assessments of residual disease (RD) to those identified on postoperative computed tomography (CT) scans in patients with advanced ovarian carcinoma reported to have undergone optimal primary cytoreduction. Patients and Methods: All patients at one of two institutions, who were scheduled to have primary surgery for presumed advanced ovarian cancer, were asked to consent to a postoperative CT scan if cytoreduction to ≤ 1 cm RD was reported. CT scan findings were graded using a qualitative analysis scale from 1 (normal) to 5 (definitely malignant). Results: From January 2001 to September 2006, 285 patients were enrolled. A total of 78 patients met eligibility criteria and had postoperative CT scans. In 41 cases (52%), postoperative scan findings correlated with the surgical report of no RD more than 1 cm, and in seven cases (9%), the CT findings were indeterminate. In 10 cases (13%), more than 1 cm RD was noted by the radiologist as probably malignant, and in 20 cases (26%), definitely malignant. In these 30 cases, the radiologically reported median largest residual mass was 1.9 cm (range, 1.1 to 5.1), with RD more than 1 cm reported most commonly in the right upper quadrant (15 patients [50%]) and central abdomen (nine patients [30%]). Conclusion: There was only a 52% correlation between surgeons' assessments and postoperative CT scan evaluations of RD in patients reported to have undergone optimal cytoreduction. Further study is required to determine whether this lack of correlation is due to rapid interval tumor regrowth, RD underestimated by the surgeons, and/or overestimated by the radiologists; and to determine the clinical implications of these discrepancies. © 2007 by American Society of Clinical Oncology.
Keywords: adult; human tissue; aged; aged, 80 and over; middle aged; major clinical study; histopathology; advanced cancer; postoperative care; prospective studies; cytoreductive surgery; ovarian neoplasms; computer assisted tomography; peritoneal neoplasms; tomography, x-ray computed; patient assessment; minimal residual disease; neoplasm, residual; ovary carcinoma; gynecologic surgical procedures; physical examination; fallopian tube neoplasms
Journal Title: Journal of Clinical Oncology
Volume: 25
Issue: 31
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2007-11-01
Start Page: 4946
End Page: 4951
Language: English
DOI: 10.1200/jco.2007.12.2317
PUBMED: 17971592
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "CODEN: JCOND" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. William Hoskins
    137 Hoskins
  2. Richard R Barakat
    588 Barakat
  3. Carol Brown
    116 Brown
  4. Dennis S Chi
    495 Chi
  5. Yukio Sonoda
    286 Sonoda
  6. Douglas A Levine
    356 Levine
  7. Svetlana Mironov
    37 Mironov
  8. Hedvig Hricak
    330 Hricak