Dissecting factors influencing response to CAR T cell therapy in B lymphoid hematologic malignancies: From basic to practice Review
| Authors: | Wudhikarn, K.; Park, J. H. |
| Review Title: | Dissecting factors influencing response to CAR T cell therapy in B lymphoid hematologic malignancies: From basic to practice |
| Abstract: | Over the past recent years, CD19-targeted chimeric antigen receptor T (CAR T) cell has transformed the treatment of relapsed/refractory (R/R) B lymphoid hematologic malignancy. CAR T cell therapy elicits an excellent anti-tumor effect and extends long-term disease-free remission in these difficult-to-treat patients. Notwithstanding, despite the impressive anti-tumor efficacy, some patients fail to attain clinical response or relapse after extended follow-up. The success of CAR T cell therapy involves complex interplays between host, tumor, and CAR T cell-associated arrays. Researchers have extensively explored potential predictive biomarkers for response to CAR T cell therapy. Ability to identify clinical and biological factors associated with improved response will help determine appropriate patients for CAR T cell treatment and enhance the clinical outcome of this novel therapeutic approach. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | leukemia; immunotherapy; lymphoma; chimeric antigen receptor t cell (car t cell) |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 61 |
| Issue: | 10 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2020-01-01 |
| Start Page: | 2324 |
| End Page: | 2334 |
| Language: | English |
| DOI: | 10.1080/10428194.2020.1761967 |
| PUBMED: | 32522059 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 October 2020 -- Source: Scopus |
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