Dermatologic toxicities to immune checkpoint inhibitor therapy: A review of histopathologic features Review
| Authors: | Ellis, S. R.; Vierra, A. T.; Millsop, J. W.; Lacouture, M. E.; Kiuru, M. |
| Review Title: | Dermatologic toxicities to immune checkpoint inhibitor therapy: A review of histopathologic features |
| Abstract: | Antineoplastic agents that use the immune system have revolutionized cancer treatment. Specifically, implementation of immune checkpoint inhibitors, monoclonal antibodies that block cytotoxic T-lymphocyte–associated antigen-4, programmed cell death protein 1, or programmed cell death ligand 1 show improved and sustained responses in patients with cancer. However, these agents are associated with a plethora of adverse events, many manifesting in the skin. As the clinical application of cancer immunotherapies expands, understanding the clinical and histopathologic features of associated cutaneous toxicities becomes increasingly important to dermatologists, oncologists, and pathologists to ensure timely diagnosis and appropriate care. This review discusses cutaneous reactions to immune checkpoint inhibitors, focusing on histopathologic features. © 2020 American Academy of Dermatology, Inc. |
| Keywords: | unclassified drug; histopathology; skin toxicity; ipilimumab; tumor regression; keratinocyte; psoriasis; rash; skin; immunotherapy; cutaneous; panniculitis; hair disease; dermatitis; ctla-4; toxicity; alopecia; pyoderma gangrenosum; lichenoid eruption; stevens johnson syndrome; toxic epidermal necrolysis; adverse event; pd-l1; vitiligo; pigmented nevus; acute febrile neutrophilic dermatosis; acute generalized exanthematous pustulosis; immune checkpoint inhibitor; nivolumab; human; priority journal; article; checkpoint inhibitor; pembrolizumab; durvalumab; acantholysis; atezolizumab; avelumab; lichenoid dermatitis; immunological antineoplastic agent; pd1; bullous pemphigoid |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 83 |
| Issue: | 4 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2020-10-01 |
| Start Page: | 1130 |
| End Page: | 1143 |
| Language: | English |
| DOI: | 10.1016/j.jaad.2020.04.105 |
| PUBMED: | 32360716 |
| PROVIDER: | scopus |
| PMCID: | PMC7492441 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 October 2020 -- Source: Scopus |
