Role of radiation therapy in Hodgkin's lymphoma Journal Article
| Author: | Yahalom, J. |
| Article Title: | Role of radiation therapy in Hodgkin's lymphoma |
| Abstract: | Radiation therapy was the first modality that solely cured patients with Hodgkin's lymphoma (HL) as early as the 1940s. In the absence of other curative options, the radiation field in full dose was extended to encompass both involved and uninvolved sites including many normal organs. Decades later, it was evident that some of the HL survivors succumbed to radiation-related effects, mostly second solid tumors. The more recent reliance on modern chemotherapy in combination with radiation yielded further improvement in disease control and allowed a marked reduction in radiation exposure. Some oncologists even suggested that chemotherapy alone might retain the excellent results obtained with combined modality and campaigned for the exclusion of radiotherapy from the treatment program. However, analysis of randomized studies (as discussed later) supports the inclusion of reduced-field and dose radiotherapy in treatment programs for HL. Furthermore, new concerns regarding the shortand long-term safety of enhancing chemotherapy to compensate for the omission of radiotherapy favor shorter courses of chemotherapy. Short chemotherapy supplemented with mini-radiotherapy constitutes a highly effective and safe treatment of HL, particularly in early stages. Copyright © 2009 by Lippincott Williams & Wilkins. |
| Keywords: | cancer chemotherapy; cancer survival; overall survival; prednisone; clinical trial; review; salvage therapy; doxorubicin; drug safety; multimodality cancer therapy; solid tumor; antineoplastic agents; cancer radiotherapy; radiation dose; combined modality therapy; chemotherapy; dacarbazine; multiple cycle treatment; etoposide; antineoplastic combined chemotherapy protocols; radiotherapy; cyclophosphamide; vincristine; autologous stem cell transplantation; radiation injury; chlormethine; procarbazine; vinblastine; hodgkin disease; radiation exposure; radiation response; cancer survivor; health program; vincristine sulfate; hodgkin's lymphoma; disease progression; dactinomycin; bleomycin; cancer relapse; epirubicin; second cancer; disease control; radiation field; lymph node irradiation; nodular lymphocyte predominant hodgkin lymphoma; mini-radiotherapy |
| Journal Title: | The Cancer Journal |
| Volume: | 15 |
| Issue: | 2 |
| ISSN: | 1528-9117 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2009-01-01 |
| Start Page: | 155 |
| End Page: | 160 |
| Language: | English |
| DOI: | 10.1097/PPO.0b013e3181a1437a |
| PUBMED: | 19390312 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: CAJOC" - "Source: Scopus" |
