PET/CT imaging with an (18)F-labeled galactodendritic unit in a Galectin-1–overexpressing orthotopic bladder cancer model Journal Article

   


Authors: Pereira, P. M. R.; Roberts, S.; Figueira, F.; Tomé, J. P. C.; Reiner, T.; Lewis, J. S.
Article Title: PET/CT imaging with an (18)F-labeled galactodendritic unit in a Galectin-1–overexpressing orthotopic bladder cancer model
Abstract: Galectins are carbohydrate-binding proteins overexpressed in bladder cancer (BCa) cells. Dendritic galactose moieties have a high affinity for galectin-expressing tumor cells. We radiolabeled a dendritic galactose carbohydrate with 18F (18F-labeled galactodendritic unit 4) and examined its potential in imaging urothelial malignancies. Methods: The 18F-labeled first-generation galactodendritic unit 4 was obtained from its tosylate precursor. We conducted in vivo studies in a galectin-expressing UMUC3 orthotopic BCa model to determine the ability of 18F-labeled galactodendritic unit 4 to image BCa. Results: Intravesical administration of 18F-labeled galactodendritic unit 4 allowed specific accumulation of the carbohydrate radiotracer in galectin-1–overexpressing UMUC3 orthotopic tumors when imaged with PET. The 18F-labeled galactodendritic unit 4 was not found to accumulate in nontumor murine bladders. Conclusion: The 18F-labeled galactodendritic unit 4 and similar analogs may be clinically relevant and exploitable for PET imaging of galectin-1–overexpressing bladder tumors. © 2020 by the Society of Nuclear Medicine and Molecular Imaging
Keywords: bladder cancer; pet/ct imaging; galectins; 18f-radiochemistry; dendritic carbohydrate
Journal Title: Journal of Nuclear Medicine
Volume: 61
Issue: 9
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 2020-09-01
Start Page: 1369
End Page: 1375
Language: English
DOI: 10.2967/jnumed.119.236430
PUBMED: 32005776
PROVIDER: scopus
PMCID: PMC7456169
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090249662&doi=10.2967%2fjnumed.119.236430&partnerID=40&md5=5799e16a6f39087029e200f0c26e70c1
Notes: Article -- Source: Scopus
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MSK Authors
  1. Jason S Lewis
    456 Lewis
  2. Thomas Reiner
    136 Reiner
  3. Patricia Manuela Ribeiro Pereira
    21 Ribeiro Pereira
  4. Sheryl Roberts
    23 Roberts
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