The unique pharmacometrics of small molecule therapeutic drug tracer imaging for clinical oncology Review

   


Authors: Dunphy, M. P. S.; Pillarsetty, N.
Review Title: The unique pharmacometrics of small molecule therapeutic drug tracer imaging for clinical oncology
Abstract: Translational development of radiolabeled analogues or isotopologues of small molecule therapeutic drugs as clinical imaging biomarkers for optimizing patient outcomes in targeted cancer therapy aims to address an urgent and recurring clinical need in therapeutic cancer drug development: drug-and target-specific biomarker assays that can optimize patient selection, dosing strategy, and response assessment. Imaging the in vivo tumor pharmacokinetics and biomolecular pharmacodynamics of small molecule cancer drugs offers patient-and tumor-specific data which are not available from other pharmacometric modalities. This review article examines clinical research with a growing pharmacopoeia of investigational small molecule cancer drug tracers. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords: pharmacokinetics; theranostics; predictive biomarkers; diagnostic biomarkers; imaging biomarkers; small molecule drugs
Journal Title: Cancers
Volume: 12
Issue: 9
ISSN: 2072-6694
Publisher: MDPI  
Date Published: 2020-09-01
Start Page: 2712
Language: English
DOI: 10.3390/cancers12092712
PROVIDER: scopus
PUBMED: 32971780
PMCID: PMC7563483
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091299876&doi=10.3390%2fcancers12092712&partnerID=40&md5=fdf7b546494820d6099682482acf70a5
Notes: Review -- Export Date: 1 October 2020 -- Source: Scopus
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MSK Authors
  1. Nagavarakishore Pillarsetty
    132 Pillarsetty
  2. Mark Phillip Dunphy
    81 Dunphy
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