Does radiotherapy still have a place in Hodgkin lymphoma? Journal Article
| Author: | Yahalom, J. |
| Article Title: | Does radiotherapy still have a place in Hodgkin lymphoma? |
| Abstract: | Over half a century, radiation therapy (RT) for Hodgkin lymphoma has been transformed from a radical, extensive, high-dose therapy (which alone cured most patients) into an essential component of a comprehensive combined-modality program. RT is now used in a "mini" version that encompasses only the clinically involved sites following chemotherapy and is administered in a markedly reduced dose. This change has considerably reduced the long-term complications that were associated with the now-outdated radical RT approach. The use of RT also allows a shorter and safer course of chemotherapy. The combination of reduced chemotherapy followed by mini-RT has produced disease control and even overall results that are significantly superior to those achieved with chemotherapy alone. This review discusses controversial issues regarding RT, the studies that have addressed them, the new indications for integrating RT, and the safety of minimizing the radiation field and dose. © Current Medicine Group, LLC 2009. |
| Keywords: | cancer chemotherapy; cancer survival; event free survival; treatment outcome; treatment response; survival analysis; overall survival; prednisone; clinical trial; review; salvage therapy; doxorubicin; advanced cancer; drug efficacy; monotherapy; clinical trials as topic; cancer radiotherapy; radiation dose; combined modality therapy; neoplasm staging; treatment indication; dacarbazine; progression free survival; multiple cycle treatment; antineoplastic combined chemotherapy protocols; radiotherapy dosage; cyclophosphamide; vincristine; autologous stem cell transplantation; cancer mortality; chlormethine; procarbazine; vinblastine; hodgkin disease; patient safety; bleomycin; clinical effectiveness; radiation field; nodular lymphocyte predominant hodgkin lymphoma |
| Journal Title: | Current Hematologic Malignancy Reports |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 1558-8211 |
| Publisher: | Springer |
| Date Published: | 2009-07-01 |
| Start Page: | 117 |
| End Page: | 124 |
| Language: | English |
| DOI: | 10.1007/s11899-009-0017-2 |
| PUBMED: | 20425424 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "Source: Scopus" |
