Recurrence and morbidity in differentiated thyroid carcinoma in children Journal Article
| Authors: | La Quaglia, M. P.; Corbally, M. T.; Heller, G.; Exelby, P. R.; Brennan, M. F. |
| Article Title: | Recurrence and morbidity in differentiated thyroid carcinoma in children |
| Abstract: | The management of differentiated thyroid cancer in childhood is controversial. In particular, the role of aggressive surgical treatment has been questioned. This study was performed to identify those factors that are predictive of recurrence and morbidity following treatment through use of a multivariate model. The records of all patients 17 years of age or less admitted in the last 35 years with histologically confirmed differentiated thyroid carcinoma were reviewed. Data were sufficient for multivariate analysis in 93. The mean age at diagnosis was 13.3 years, and the median period of follow-up was 20 years. Seventy-one percent of the patients had nodal metastases. There were no deaths from thyroid carcinoma in this series, and the overall recurrence rate after initial treatment was 34%. Multivariate analysis demonstrated that only age (p ≤ 0.07) and histologic subtype (p ≤ 0.01) were predictive of time to recurrence. Major morbidity was a function of age (p ≤ 0.007) and extent of thyroid surgery (p ≤ 0.01). Probability of minor complications was predicted by use of radical neck dissection (p ≤ 0.02). Use of total or subtotal thyroidectomy or of radical neck dissection in children does not prevent recurrence and is associated with an increased risk of complications. We conclude that these procedures should be avoided in pediatric patients. © 1988. |
| Keywords: | adolescent; child; retrospective studies; major clinical study; neck dissection; methodology; lymphatic metastasis; neoplasm recurrence, local; statistics; morbidity; histology; age; models, theoretical; postoperative complication; postoperative complications; iodine 131; diagnosis; carcinoma; recurrent disease; thyroidectomy; thyroid cancer; thyroid neoplasms; thyroglobulin; thyroid gland; thyroxine; subtotal thyroidectomy; human; male; female; priority journal |
| Journal Title: | Surgery |
| Volume: | 104 |
| Issue: | 6 |
| ISSN: | 0039-6060 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1988-12-01 |
| Start Page: | 1149 |
| End Page: | 1156 |
| Language: | English |
| PUBMED: | 3194842 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
Citation Impact
MSK Authors
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1059Brennan -
411La Quaglia -
399Heller -
30Exelby -
14Corbally
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