Leukaemic B cells from patients with chronic lymphocytic leukaemia suppress immunoglobulin production by lymphocytes from normal donors Journal Article

  

Authors:	Kunicka, J.; Platsoucas, C. D.
Article Title:	Leukaemic B cells from patients with chronic lymphocytic leukaemia suppress immunoglobulin production by lymphocytes from normal donors
Abstract:	We observed that highly purified E‐rosette‐negative largely leukaemic B cells from 9 out of 15 patients with chronic lymphocytic leukaemia (CLL) significantly suppressed immunoglobulin production by mixtures of T4 and B cells from normal donors in the presence of pokeweed mitogen (PWM). This suppression by leukaemic B cells was concentration‐dependent. Addition of equal numbers of B cells from normal donor to the mixtures of normal T4 and B cells increased, or had no effect on the production of IgM, IgA, and IgG Treatment of purified largely leukaemic B cells from patterns with CLL with either the anti‐B1 or anti‐Leu 1 monoclonal antibody plus complement abolished their ability to suppress immunoglobulin production. In contrast, treatment with either the anti‐Leu 5 or the OKMI monoclonal antibody plus complement had no effect on the suppression. These results tugged that leukaemic B cells from certain patients with CLL may exhibit, or can be induced to exhibit, immunosuppressive properties. Copyright © 1988, Wiley Blackwell. All rights reserved
Keywords:	leukemia; human cell; phenotype; b lymphocyte; b-lymphocytes; antibodies, monoclonal; cell culture; chronic lymphatic leukemia; immunosuppressive agent; normal human; blood donors; immunoglobulins; antigens, differentiation, b-lymphocyte; leukemia, lymphocytic; human; priority journal; agammaglobulinemia; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; immunoglobulin production; t-lymphocytes, suppressor-effector; pokeweed mitogen; antibody-producing cells
Journal Title:	Scandinavian Journal of Immunology
Volume:	28
Issue:	1
ISSN:	0300-9475
Publisher:	John Wiley & Sons
Date Published:	1988-07-01
Start Page:	1
End Page:	10
Language:	English
DOI:	10.1111/j.1365-3083.1988.tb02409.x
PUBMED:	2969611
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023688266&doi=10.1111%2fj.1365-3083.1988.tb02409.x&partnerID=40&md5=b8589223553ea3e3524dc41e45d4e09c
Notes:	Article -- Export Date: 6 August 2020 -- Source: Scopus

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