Cyclophosphamide and bone marrow transplantation - To the editor Journal Article

  


Author: Brochstein, J. A.
Article Title: Cyclophosphamide and bone marrow transplantation - To the editor
Abstract: To the Editor: In their article on allogeneic bone marrow transplantation in children, Brochstein et al. (Dec. 24 issue)1 comment that the conventional treatment with cyclophosphamide followed by total-body irradiation for cytoreduction before transplantation may not be as beneficial as the use of these same methods in the reverse order. It has been known for some time that there is an unacceptable graft-rejection rate of 25 to 60 percent after pretransplantation treatment with cyclophosphamide alone.2 For that reason, total-body irradiation in various dosages has been added to cyclophosphamide at most institutions as part of the conditioning regimen.34 Recently, I had. © 1988, Massachusetts Medical Society. All rights reserved.
Keywords: child; child, preschool; letter; bone marrow; cyclophosphamide; lymphatic leukemia; drug therapy; bone marrow transplantation; immunosuppressive agent; whole-body irradiation; leukemia, lymphocytic; human; female; priority journal
Journal Title: New England Journal of Medicine
Volume: 318
Issue: 23
ISSN: 0028-4793
Publisher: Massachusetts Medical Society  
Date Published: 1988-06-09
Start Page: 1541
End Page: 1542
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023909732&doi=10.1056%2fNEJM198806093182315&partnerID=40&md5=ecf4e96cd45ff9c852770487ba230d31
Notes: Letter part of PMID: 3285218, DOI: 10.1056/nejm198806093182315 -- Export Date: 6 August 2020 -- Source: Scopus